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update

rdmorin committed 2025-01-16 08:57:18 -0800 commit dd099b84f98061934b33e6e43c055783a2862880

				ATM.md
			
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           ## Overview

           Mutations in this gene were first described in MZL by Braggio et al.[@braggioGenomicAnalysisMarginal2012] then in MCL by Bea et al.[@beaLandscapeSomaticMutations2013] ATM mutations were later described in DLBCL by Reddy et al.[@reddyGeneticFunctionalDrivers2017]

          -Although there is [experimental data](#experimental-evidence) supporting its relevance in MCL, the role of ATM in DLBCL remains unclear.

          +Although there is [experimental data](#experimental-evidence) supporting the role of loss-of-function mutations in MCL biology, the relevance of ATM mutations in DLBCL remains unclear.

           [Selective pressure analysis](#mutation-pattern-and-selective-pressure-estimates) did not identify this gene as significantly enriched for either missense or truncating mutations, indicating that many of these mutations may represent passengers.

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10	10	## Overview
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12	12	Mutations in this gene were first described in MZL by Braggio et al.[@braggioGenomicAnalysisMarginal2012] then in MCL by Bea et al.[@beaLandscapeSomaticMutations2013] ATM mutations were later described in DLBCL by Reddy et al.[@reddyGeneticFunctionalDrivers2017]
13		-Although there is [experimental data](#experimental-evidence) supporting its relevance in MCL, the role of ATM in DLBCL remains unclear.
	13	+Although there is [experimental data](#experimental-evidence) supporting the role of loss-of-function mutations in MCL biology, the relevance of ATM mutations in DLBCL remains unclear.
14	14	[Selective pressure analysis](#mutation-pattern-and-selective-pressure-estimates) did not identify this gene as significantly enriched for either missense or truncating mutations, indicating that many of these mutations may represent passengers.
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