morinlab.bib
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+@article{choiLossKLHL6Promotes2018,
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+ title = {Loss of {{KLHL6}} Promotes Diffuse Large {{B-cell}} Lymphoma Growth and Survival by Stabilizing the {{mRNA}} Decay Factor Roquin2},
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+ author = {Choi, Jaewoo and Lee, Kyutae and Ingvarsdottir, Kristin and Bonasio, Roberto and Saraf, Anita and Florens, Laurence and Washburn, Michael P. and Tadros, Saber and Green, Michael R. and Busino, Luca},
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+ date = {2018-05},
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+ journaltitle = {Nature Cell Biology},
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+ shortjournal = {Nat Cell Biol},
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+ volume = {20},
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+ number = {5},
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+ eprint = {29695787},
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+ eprinttype = {pmid},
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+ pages = {586--596},
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+ issn = {1476-4679},
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+ doi = {10.1038/s41556-018-0084-5},
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+ abstract = {Kelch-like protein 6 (KLHL6) is an uncharacterized gene mutated in diffuse large B-cell lymphoma (DLBCL). Here we report that KLHL6 assembles with cullin3 to form a functional cullin-RING ubiquitin ligase. Mutations in KLHL6 inhibit its ligase activity by disrupting the interaction with cullin3. Loss of KLHL6 favours DLBCL growth and survival both in vitro and in xenograft models. We further established that the mRNA decay factor roquin2 is a substrate of KLHL6. Degradation of roquin2 is dependent on B-cell receptor activation, and requires the integrity of the Tyr691 residue in roquin2 that is essential for its interaction with KLHL6. A non-degradable roquin2(Y691F) mutant requires its RNA-binding ability to phenocopy the effect of KLHL6 loss. Stabilization of roquin2 promotes mRNA decay of the tumour suppressor and NF-κB pathway inhibitor, tumour necrosis factor-α-inducible gene 3. Collectively, our findings uncover the tumour suppressing mechanism of KLHL6.},
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+ langid = {english},
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+ pmcid = {PMC5926793},
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+ keywords = {Animals,Carrier Proteins,Cell Line Tumor,Cell Proliferation,Cell Survival,Gene Expression Regulation Enzymologic,Gene Expression Regulation Neoplastic,HEK293 Cells,Humans,Lymphoma Large B-Cell Diffuse,Mice Inbred NOD,Mice SCID,Mutation,NF-kappa B,Protein Stability,Proteolysis,Receptors Antigen B-Cell,Repressor Proteins,RNA Messenger,RNA Stability,Signal Transduction,Tumor Necrosis Factor alpha-Induced Protein 3,Tumor Suppressor Proteins,Tyrosine,Ubiquitination},
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+}
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+
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@article{mansouriFunctionalLossIkBe2015,
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title = {Functional Loss of {{IκBε}} Leads to {{NF-κB}} Deregulation in Aggressive Chronic Lymphocytic Leukemia},
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author = {Mansouri, Larry and Sutton, Lesley-Ann and Ljungström, Viktor and Bondza, Sina and Arngården, Linda and Bhoi, Sujata and Larsson, Jimmy and Cortese, Diego and Kalushkova, Antonia and Plevova, Karla and Young, Emma and Gunnarsson, Rebeqa and Falk-Sörqvist, Elin and Lönn, Peter and Muggen, Alice F. and Yan, Xiao-Jie and Sander, Birgitta and Enblad, Gunilla and Smedby, Karin E. and Juliusson, Gunnar and Belessi, Chrysoula and Rung, Johan and Chiorazzi, Nicholas and Strefford, Jonathan C. and Langerak, Anton W. and Pospisilova, Sarka and Davi, Frederic and Hellström, Mats and Jernberg-Wiklund, Helena and Ghia, Paolo and Söderberg, Ola and Stamatopoulos, Kostas and Nilsson, Mats and Rosenquist, Richard},