ACTB.md
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ACTB is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas. The function of mutations in ACTB and ACTG1 have not yet been determined.[@witjesPrevalenceCytoplasmicActin2020b]
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+## Relevance tier by entity
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+
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+|Entity|Tier|Description |
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+|:------:|:----:|--------------------------|
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+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
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+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@wienandGenomicAnalysesFlowsorted2019b]|
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+|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene, hypermutated[@lohrDiscoveryPrioritizationSomatic2012a]|
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+|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene, hypermutated |
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+
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## History
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```mermaid
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%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
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2021-05-05 : Hubschmann : DLBCL
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```
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-## Relevance tier by entity
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-
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-|Entity|Tier|Description |
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-|:------:|:----:|--------------------------|
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-|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
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-|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@wienandGenomicAnalysesFlowsorted2019b]|
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-|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene, hypermutated[@lohrDiscoveryPrioritizationSomatic2012a]|
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-|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene, hypermutated |
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-
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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|Entity|source |frequency (%)|