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rdmorin committed 2025-01-18 10:59:04 -0800 commit e092b8a428d87324862e8fc779e0cc2ecf8b5749

				KMT2C.md
			
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          -<<Note("Overall, the pattern of mutations in KMT2C does not support its role in any of these entities!")>>

          +<<Note("The pattern of mutations in KMT2C does not support its role in DLBCL")>>

           ## Overview

           This gene has been reported to be recurrently mutated in DLBCL. The rate of mutations in KMT2C (MLL3) varies across published cohorts. In the initial study describing these mutations, it was suggested to be mutated in >15% of DLBCLs.[@sarkozyMutationalLandscapeGray2021] The actual rate of mutations may be much lower,[@zhouSporadicEndemicBurkitt2019] potentially due to the existence of germline variants in some studies.[@zhangGeneticHeterogeneityDiffuse2013] A more recent study suggested KMT2C mutations were more common in DLBCLs in patients of African ancestry.[@reddyGeneticFunctionalDrivers2017] Although KMT2C mutations have been described as a feature of MCL in a single study, this pattern was not reproduced in other cohorts.[@zhangGenomicLandscapeMantle2014]

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10		-<<Note("Overall, the pattern of mutations in KMT2C does not support its role in any of these entities!")>>
	10	+<<Note("The pattern of mutations in KMT2C does not support its role in DLBCL")>>
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12	12	## Overview
13	13	This gene has been reported to be recurrently mutated in DLBCL. The rate of mutations in KMT2C (MLL3) varies across published cohorts. In the initial study describing these mutations, it was suggested to be mutated in >15% of DLBCLs.[@sarkozyMutationalLandscapeGray2021] The actual rate of mutations may be much lower,[@zhouSporadicEndemicBurkitt2019] potentially due to the existence of germline variants in some studies.[@zhangGeneticHeterogeneityDiffuse2013] A more recent study suggested KMT2C mutations were more common in DLBCLs in patients of African ancestry.[@reddyGeneticFunctionalDrivers2017] Although KMT2C mutations have been described as a feature of MCL in a single study, this pattern was not reproduced in other cohorts.[@zhangGenomicLandscapeMantle2014]