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To get started, select one of the gene lists from the table below then select the `gene page` link for any gene in the table or explore the genes nominated by [individual studies](Papers).
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-## Categorization
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-### Gene Tiers
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-**Tier 2** - Any gene described as significantly or recurrently mutated in one or more types of B-cell lymphoma is initially assigned to Tier 2 for that entity. The study describing the mutation of that gene in a particular entity is considered the originating study.
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-**Tier 1** - Genes can transition to Tier 1 only after additional studies have demonstrated the recurrence of mutations in the same entity.
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-### Gene Designations
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-**aSHM** - Denotes genes as affected by aberrant somatic hypermutation (aSHM). Tier 1 and Tier 2 genes can have this designation, respectively abbreviated as *1-a* and *2-a*. For example, see [BCL7A](BCL7A).
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-**Fail** - Some studies with large additions to Tier 2 lists have undergone manual review of the primary data. If the majority of mutations in a gene fail QC, the gene will be given the designation *2-F*. For example, see [MARK1](MARK1).
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```mermaid
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|[@paneaWholeGenomeLandscape2019](papers/paneaWholeGenomeLandscape2019)|BL|4|22 (55%)|
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|[@hubschmannMutationalMechanismsShaping2021b](papers/hubschmannMutationalMechanismsShaping2021b)|DLBCL,FL|4|TBD|
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+## Categorization
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+### Gene Tiers
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+**Tier 2** - Any gene described as significantly or recurrently mutated in one or more types of B-cell lymphoma is initially assigned to Tier 2 for that entity. The study describing the mutation of that gene in a particular entity is considered the originating study.
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+**Tier 1** - Genes can transition to Tier 1 only after additional studies have demonstrated the recurrence of mutations in the same entity.
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+### Gene Designations
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+**aSHM** - Denotes genes as affected by aberrant somatic hypermutation (aSHM). Tier 1 and Tier 2 genes can have this designation, respectively abbreviated as *1-a* and *2-a*. For example, see [BCL7A](BCL7A).
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+**Fail** - Some studies with large additions to Tier 2 lists have undergone manual review of the primary data. If the majority of mutations in a gene fail QC, the gene will be given the designation *2-F*. For example, see [MARK1](MARK1).
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## B-cell lymphoma mutation browser
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![](images/proteinpaint/FOXO1_NM_002015.svg)