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rdmorin committed 2024-06-08 13:22:33 -0700 commit e62df1dcac27c69cbd03813c61bca3a5c8dcf59f

				DDX3X.md
			
          @@ -7,7 +7,7 @@ link-citations: true

           ## Overview

           Mutations in the DDX3X gene, which encodes an RNA helicase involved in various aspects of RNA metabolism, have significant implications in B-cell lymphomas, including BL, DLBCL, and other related malignancies and are particularly enriched within MYC-translocated tumors and those expressing the dark zone signature (DZsig).[@ennishiDoubleHitGeneExpression2019] 

          -These mutations are predominantly loss-of-function (LOF) mutations, affecting the helicase domain of the protein.<sup>2</sup> Missense mutations are predominantly found in male patients and rarely in females, hence showing a sex-specific pattern.<sup>3</sup> 

          +These mutations are predominantly loss-of-function (LOF) mutations, affecting the helicase domain of the protein. Missense mutations are predominantly found in male patients and rarely in females, hence showing a sex-specific pattern.[@gongSequentialInverseDysregulation2021]

           ## History

           ```mermaid

...	...	@@ -7,7 +7,7 @@ link-citations: true
7	7
8	8	## Overview
9	9	Mutations in the DDX3X gene, which encodes an RNA helicase involved in various aspects of RNA metabolism, have significant implications in B-cell lymphomas, including BL, DLBCL, and other related malignancies and are particularly enriched within MYC-translocated tumors and those expressing the dark zone signature (DZsig).[@ennishiDoubleHitGeneExpression2019]
10		-These mutations are predominantly loss-of-function (LOF) mutations, affecting the helicase domain of the protein.<sup>2</sup> Missense mutations are predominantly found in male patients and rarely in females, hence showing a sex-specific pattern.<sup>3</sup>
	10	+These mutations are predominantly loss-of-function (LOF) mutations, affecting the helicase domain of the protein. Missense mutations are predominantly found in male patients and rarely in females, hence showing a sex-specific pattern.[@gongSequentialInverseDysregulation2021]
11	11
12	12	## History
13	13	```mermaid