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Updated HNRNPH1 (markdown)

rdmorin committed 2024-05-21 12:59:55 -0700 commit e6e75a3f16ba2b6a79ffb1344f6edc0c6018ac3d

				HNRNPH1.md
			
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           # HNRNPH1

           ## Overview

          -Mutations in HNRNPH1 are enriched at splicing signals in exon 4. These result in deregulated splicing and increased expression of the hnRNP H1 protein. This overexpression is linked to enhanced cell proliferation and survival, contributing to the aggressive nature of MCL.<sup>1,2</sup> 

          +Mutations in HNRNPH1 are enriched at splicing signals in exon 4. These result in deregulated splicing and increased expression of the hnRNP H1 protein. This overexpression is linked to enhanced cell proliferation and survival, contributing to the aggressive nature of MCL. <sup>1,2</sup> Although initially characterized in MCL, the same pattern of mutations appears in a small number of DLBCLs.

           ## Relevance tier by entity

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1	1	# HNRNPH1
2	2	## Overview
3		-Mutations in HNRNPH1 are enriched at splicing signals in exon 4. These result in deregulated splicing and increased expression of the hnRNP H1 protein. This overexpression is linked to enhanced cell proliferation and survival, contributing to the aggressive nature of MCL.<sup>1,2</sup>
	3	+Mutations in HNRNPH1 are enriched at splicing signals in exon 4. These result in deregulated splicing and increased expression of the hnRNP H1 protein. This overexpression is linked to enhanced cell proliferation and survival, contributing to the aggressive nature of MCL. <sup>1,2</sup> Although initially characterized in MCL, the same pattern of mutations appears in a small number of DLBCLs.
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5	5	## Relevance tier by entity
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