CCND3.md
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+---
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+bibliography: 'morinlab.bib'
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+csl: 'NLM.csl'
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+link-citations: true
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+---
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# CCND3
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## Overview
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------|
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-|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
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-|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
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-|![BL](images/icons/BL_tier1.png) |1 |high-confidence BL gene |
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-|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
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-|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
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+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene[@jalladesExomeSequencingIdentifies2017]|
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+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established[@deschGenotypingCirculatingTumor2020]|
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+|![BL](images/icons/BL_tier1.png) |1 |high-confidence BL gene [@richterRecurrentMutationID32012a]|
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+|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene[@morinFrequentMutationHistonemodifying2011]|
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+|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene [@morinFrequentMutationHistonemodifying2011]|
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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![](images/proteinpaint/CCND3.svg)
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-## References
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-1. *Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011 Jul 27;476(7360):298-303. doi: 10.1038/nature10351. PMID: 21796119; PMCID: PMC3210554.*
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-2. *Schmitz, R., et al. (2012). "Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics." Nature, 490(7418), 116-120.*
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## CCND3 Expression
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![](images/gene_expression/CCND3_by_pathology.svg)
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<!-- ORIGIN: morinFrequentMutationHistonemodifying2011 -->
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<!-- DLBCL: morinFrequentMutationHistonemodifying2011 -->
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<!-- MZL: jalladesExomeSequencingIdentifies2017 -->
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<!-- PMBL: deschGenotypingCirculatingTumor2020 -->
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+## References
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