Changes in ef1d51f: more fixes

				morinlab.bib
			
          @@ -1,3 +1,23 @@

          +@article{freieGermlinePointMutation2024,

          +  title = {A Germline Point Mutation in the {{MYC-FBW7}} Phosphodegron Initiates Hematopoietic Malignancies},

          +  author = {Freie, Brian and Carroll, Patrick A. and Varnum-Finney, Barbara J. and Ramsey, Erin L. and Ramani, Vijay and Bernstein, Irwin and Eisenman, Robert N.},

          +  date = {2024-04-17},

          +  journaltitle = {Genes \& Development},

          +  shortjournal = {Genes Dev},

          +  volume = {38},

          +  number = {5-6},

          +  eprint = {38565249},

          +  eprinttype = {pmid},

          +  pages = {253--272},

          +  issn = {1549-5477},

          +  doi = {10.1101/gad.351292.123},

          +  abstract = {Oncogenic activation of MYC in cancers predominantly involves increased transcription rather than coding region mutations. However, MYC-dependent lymphomas frequently acquire point mutations in the MYC phosphodegron, including at threonine 58 (T58), where phosphorylation permits binding via the FBW7 ubiquitin ligase triggering MYC degradation. To understand how T58 phosphorylation functions in normal cell physiology, we introduced an alanine mutation at T58 (T58A) into the endogenous c-Myc locus in the mouse germline. While MYC-T58A mice develop normally, lymphomas and myeloid leukemias emerge in ∼60\% of adult homozygous T58A mice. We found that primitive hematopoietic progenitor cells from MYC-T58A mice exhibit aberrant self-renewal normally associated with hematopoietic stem cells (HSCs) and up-regulate a subset of MYC target genes important in maintaining stem/progenitor cell balance. In lymphocytes, genomic occupancy by MYC-T58A was increased at all promoters compared with WT MYC, while genes differentially expressed in a T58A-dependent manner were significantly more proximal to MYC-bound enhancers. MYC-T58A lymphocyte progenitors exhibited metabolic alterations and decreased activation of inflammatory and apoptotic pathways. Our data demonstrate that a single point mutation stabilizing MYC is sufficient to skew target gene expression, producing a profound gain of function in multipotential hematopoietic progenitors associated with self-renewal and initiation of lymphomas and leukemias.},

          +  langid = {english},

          +  pmcid = {PMC11065175},

          +  keywords = {Animals,F-Box-WD Repeat-Containing Protein 7,FBW7,Germ Cells,Hematologic Neoplasms,hematopoiesis,Hematopoietic Stem Cells,leukemia,lymphoma,Lymphoma,Mice,MYC,Point Mutation,progenitor cells,protein stability,Proto-Oncogene Proteins c-myc,self-renewal},

          +  file = {/Users/rmorin/Zotero/storage/5ZEIGWRU/Freie et al. - 2024 - A germline point mutation in the MYC-FBW7 phosphod.pdf}

          +}

          +

           @article{demosthenousLossFunctionMutations2015,

             title = {Loss of Function Mutations in {{PTPN6}} Promote {{STAT3}} Deregulation via {{JAK3}} Kinase in Diffuse Large {{B-cell}} Lymphoma},

             author = {Demosthenous, Christos and Han, Jing Jing and Hu, Guangzhen and Stenson, Mary and Gupta, Mamta},

...	...	@@ -1,3 +1,23 @@
	1	+@article{freieGermlinePointMutation2024,
	2	+ title = {A Germline Point Mutation in the {{MYC-FBW7}} Phosphodegron Initiates Hematopoietic Malignancies},
	3	+ author = {Freie, Brian and Carroll, Patrick A. and Varnum-Finney, Barbara J. and Ramsey, Erin L. and Ramani, Vijay and Bernstein, Irwin and Eisenman, Robert N.},
	4	+ date = {2024-04-17},
	5	+ journaltitle = {Genes \& Development},
	6	+ shortjournal = {Genes Dev},
	7	+ volume = {38},
	8	+ number = {5-6},
	9	+ eprint = {38565249},
	10	+ eprinttype = {pmid},
	11	+ pages = {253--272},
	12	+ issn = {1549-5477},
	13	+ doi = {10.1101/gad.351292.123},
	14	+ abstract = {Oncogenic activation of MYC in cancers predominantly involves increased transcription rather than coding region mutations. However, MYC-dependent lymphomas frequently acquire point mutations in the MYC phosphodegron, including at threonine 58 (T58), where phosphorylation permits binding via the FBW7 ubiquitin ligase triggering MYC degradation. To understand how T58 phosphorylation functions in normal cell physiology, we introduced an alanine mutation at T58 (T58A) into the endogenous c-Myc locus in the mouse germline. While MYC-T58A mice develop normally, lymphomas and myeloid leukemias emerge in ∼60\% of adult homozygous T58A mice. We found that primitive hematopoietic progenitor cells from MYC-T58A mice exhibit aberrant self-renewal normally associated with hematopoietic stem cells (HSCs) and up-regulate a subset of MYC target genes important in maintaining stem/progenitor cell balance. In lymphocytes, genomic occupancy by MYC-T58A was increased at all promoters compared with WT MYC, while genes differentially expressed in a T58A-dependent manner were significantly more proximal to MYC-bound enhancers. MYC-T58A lymphocyte progenitors exhibited metabolic alterations and decreased activation of inflammatory and apoptotic pathways. Our data demonstrate that a single point mutation stabilizing MYC is sufficient to skew target gene expression, producing a profound gain of function in multipotential hematopoietic progenitors associated with self-renewal and initiation of lymphomas and leukemias.},
	15	+ langid = {english},
	16	+ pmcid = {PMC11065175},
	17	+ keywords = {Animals,F-Box-WD Repeat-Containing Protein 7,FBW7,Germ Cells,Hematologic Neoplasms,hematopoiesis,Hematopoietic Stem Cells,leukemia,lymphoma,Lymphoma,Mice,MYC,Point Mutation,progenitor cells,protein stability,Proto-Oncogene Proteins c-myc,self-renewal},
	18	+ file = {/Users/rmorin/Zotero/storage/5ZEIGWRU/Freie et al. - 2024 - A germline point mutation in the MYC-FBW7 phosphod.pdf}
	19	+}
	20	+
1	21	@article{demosthenousLossFunctionMutations2015,
2	22	title = {Loss of Function Mutations in {{PTPN6}} Promote {{STAT3}} Deregulation via {{JAK3}} Kinase in Diffuse Large {{B-cell}} Lymphoma},
3	23	author = {Demosthenous, Christos and Han, Jing Jing and Hu, Guangzhen and Stenson, Mary and Gupta, Mamta},