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## Definitions
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+### Tiers
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**Tier 2 Genes**
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Any gene described as significantly or recurrently mutated in one or more types of B-cell lymphoma is initially assigned to Tier 2 for that entity. The study describing the mutation of that gene in a particular entity is considered the originating study.
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Genes can transition to Tier 1 only after additional studies have demonstrated the recurrence of mutations in the same entity.
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+### Designations
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+**aSHM**
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+Genes documented as being affected by aberrant somatic hypermutation (aSHM) will sometimes have this designation. Tier 1 and Tier 2 genes can have this designation, depending on whether the mutation pattern has been reproduced in multiple studies.
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```mermaid
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---
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