morinlab.bib
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+@article{wanMechanismActivationRAFERK2004,
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+ title = {Mechanism of Activation of the {{RAF-ERK}} Signaling Pathway by Oncogenic Mutations of {{B-RAF}}},
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+ author = {Wan, Paul T. C. and Garnett, Mathew J. and Roe, S. Mark and Lee, Sharlene and Niculescu-Duvaz, Dan and Good, Valerie M. and Jones, C. Michael and Marshall, Christopher J. and Springer, Caroline J. and Barford, David and Marais, Richard and {Cancer Genome Project}},
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+ date = {2004-03-19},
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+ journaltitle = {Cell},
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+ shortjournal = {Cell},
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+ volume = {116},
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+ number = {6},
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+ eprint = {15035987},
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+ eprinttype = {pmid},
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+ pages = {855--867},
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+ issn = {0092-8674},
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+ doi = {10.1016/s0092-8674(04)00215-6},
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+ abstract = {Over 30 mutations of the B-RAF gene associated with human cancers have been identified, the majority of which are located within the kinase domain. Here we show that of 22 B-RAF mutants analyzed, 18 have elevated kinase activity and signal to ERK in vivo. Surprisingly, three mutants have reduced kinase activity towards MEK in vitro but, by activating C-RAF in vivo, signal to ERK in cells. The structures of wild type and oncogenic V599EB-RAF kinase domains in complex with the RAF inhibitor BAY43-9006 show that the activation segment is held in an inactive conformation by association with the P loop. The clustering of most mutations to these two regions suggests that disruption of this interaction converts B-RAF into its active conformation. The high activity mutants signal to ERK by directly phosphorylating MEK, whereas the impaired activity mutants stimulate MEK by activating endogenous C-RAF, possibly via an allosteric or transphosphorylation mechanism.},
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+ langid = {english},
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+ keywords = {Allosteric Regulation,Animals,Catalytic Domain,Cell Transformation Neoplastic,Enzyme Inhibitors,Gene Expression Regulation Enzymologic,MAP Kinase Kinase 1,MAP Kinase Signaling System,Mice,Mitogen-Activated Protein Kinase Kinases,Mitogen-Activated Protein Kinases,Models Molecular,Molecular Conformation,Mutation,Neoplasms,NIH 3T3 Cells,Oncogenes,Oocytes,Phosphorylation,Phosphotransferases,Proto-Oncogene Proteins B-raf,Proto-Oncogene Proteins c-raf,Up-Regulation,Xenopus},
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+}
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+
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@article{masclePointMutationsBCL62003,
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title = {Point Mutations in {{BCL6 DNA-binding}} Domain Reveal Distinct Roles for the Six Zinc Fingers},
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author = {Mascle, Xavier and Albagli, Olivier and Lemercier, Claudie},