BL_genes.md
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@@ -39,7 +39,7 @@ link-citations: true
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|[SMARCA4](SMARCA4)|Tier 1 GE[@richterRecurrentMutationID32012a], FE[@dengSMARCA4HaploinsufficientCell2024]|[Richter et al](papers/richterRecurrentMutationID32012a)|[@krysiakRecurrentSomaticMutations2017b; @nadeuGenomicEpigenomicInsights2020b; @reddyGeneticFunctionalDrivers2017]||
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|[TCF3](TCF3)|Tier 1 GE[@schmitzBurkittLymphomaPathogenesis2012], FE[@schmitzBurkittLymphomaPathogenesis2012]|[Schmitz et al](papers/schmitzBurkittLymphomaPathogenesis2012)|||
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|[TCL1A](TCL1A)|Tier 1 GE[@grandeGenomewideDiscoverySomatic2019]|[Grande et al](papers/grandeGenomewideDiscoverySomatic2019)|[@reddyGeneticFunctionalDrivers2017]||
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-|[TFAP4](TFAP4)|Tier 1 GE[@grandeGenomewideDiscoverySomatic2019]|[Grande et al](papers/grandeGenomewideDiscoverySomatic2019)|||
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+|[TFAP4](TFAP4)|Tier 1 GE[@grandeGenomewideDiscoverySomatic2019], FE[@toncUnexpectedSuppressionTumorigenesis2021]|[Grande et al](papers/grandeGenomewideDiscoverySomatic2019)|||
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|[TP53](TP53)|Tier 1 GE[@wildaInactivationARFMDM2p53Pathway2004], FE[@rowhTp53DeletionLineage2011]|[Wilda et al](papers/wildaInactivationARFMDM2p53Pathway2004)|[@beaLandscapeSomaticMutations2013; @lohrDiscoveryPrioritizationSomatic2012a; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012c; @tiacciPervasiveMutationsJAKSTAT2018b]||
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|[USP7](USP7)|Tier 1 GE[@grandeGenomewideDiscoverySomatic2019]|[Grande et al](papers/grandeGenomewideDiscoverySomatic2019)|[@arthurGenomewideDiscoverySomatic2018]||
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|[WNK1](WNK1)|Tier 1 GE[@thomasGeneticSubgroupsInform2023]|[Thomas et al](papers/thomasGeneticSubgroupsInform2023)|[@hubschmannMutationalMechanismsShaping2021b; @jalladesExomeSequencingIdentifies2017]||
morinlab.bib
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@@ -1,3 +1,23 @@
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+@article{toncUnexpectedSuppressionTumorigenesis2021,
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+ title = {Unexpected Suppression of Tumorigenesis by C-{{MYC}} via {{TFAP4-dependent}} Restriction of Stemness in {{B}} Lymphocytes},
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+ author = {Tonc, Elena and Takeuchi, Yoshiko and Chou, Chun and Xia, Yu and Holmgren, Melanie and Fujii, Chika and Raju, Saravanan and Chang, Gue Su and Iwamoto, Masahiro and Egawa, Takeshi},
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+ date = {2021-12-16},
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+ journaltitle = {Blood},
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+ shortjournal = {Blood},
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+ volume = {138},
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+ number = {24},
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+ eprint = {34283887},
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+ eprinttype = {pmid},
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+ pages = {2526--2538},
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+ issn = {1528-0020},
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+ doi = {10.1182/blood.2021011711},
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+ abstract = {The proliferative burst of B lymphocytes is essential for antigen receptor repertoire diversification during the development and selective expansion of antigen-specific clones during immune responses. High proliferative activity inevitably promotes oncogenesis, the risk of which is further elevated in B lymphocytes by endogenous gene rearrangement and somatic mutations. However, B-cell-derived cancers are rare, perhaps owing to putative intrinsic tumor-suppressive mechanisms. We show that c-MYC facilitates B-cell proliferation as a protumorigenic driver and unexpectedly coengages counteracting tumor suppression through its downstream factor TFAP4. TFAP4 is mutated in human lymphoid malignancies, particularly in {$>$}10\% of Burkitt lymphomas, and reduced TFAP4 expression was associated with poor survival of patients with MYC-high B-cell acute lymphoblastic leukemia. In mice, insufficient TFAP4 expression accelerated c-MYC-driven transformation of B cells. Mechanistically, c-MYC suppresses the stemness of developing B cells by inducing TFAP4 and restricting self-renewal of proliferating B cells. Thus, the pursuant transcription factor cascade functions as a tumor suppressor module that safeguards against the transformation of developing B cells.},
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+ langid = {english},
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+ pmcid = {PMC8678995},
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+ keywords = {Animals,B-Lymphocytes,Carcinogenesis,Cell Transformation Neoplastic,DNA-Binding Proteins,Gene Expression Regulation Neoplastic,Genes Tumor Suppressor,Humans,Leukemia Lymphoid,Lymphoma B-Cell,Mice,Mice Inbred C57BL,Mutation,Proto-Oncogene Proteins c-myc,Transcription Factors,Tumor Cells Cultured},
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+ file = {/Users/rmorin/Zotero/storage/LFPCKSN7/Tonc et al. - 2021 - Unexpected suppression of tumorigenesis by c-MYC v.pdf}
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+}
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+
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@article{ohayreInactivatingMutationsGNA132016,
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title = {Inactivating Mutations in {{GNA13}} and {{RHOA}} in {{Burkitt}}'s Lymphoma and Diffuse Large {{B-cell}} Lymphoma: A Tumor Suppressor Function for the {{Gα13}}/{{RhoA}} Axis in {{B}} Cells},
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shorttitle = {Inactivating Mutations in {{GNA13}} and {{RHOA}} in {{Burkitt}}'s Lymphoma and Diffuse Large {{B-cell}} Lymphoma},