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add summary

Ryan Morin committed 2024-11-26 09:52:37 -0800 commit f518427385cfb9238d918a96e95e9b41d8f66cc6

				papers/russler-germainMutationsAssociatedProgression2023.md
			
          @@ -19,7 +19,7 @@ In their 2023 study published in *Blood Advances*, Russler-Germain et al. conduc

           - Mutations in *STAT6*, *TP53*, *IGLL5*, *B2M*, *SOCS1*, and *MYD88* were more common in relapsed/refractory FL or t-FL than in newly diagnosed FL.

           ### Mutations Associated with Progression (MAP) Signature

          -- The MAP signature was defined as the presence of two or more mutations among the seven genes: *CREBBP*, *STAT6*, *TP53*, *IGLL5*, *B2M*, *SOCS1*, and *MYD8**.

          +- The MAP signature was defined as the presence of two or more mutations among the seven genes: *CREBBP*, *STAT6*, *TP53*, *IGLL5*, *B2M*, *SOCS1*, and *MYD88*.

           - Patients with newly diagnosed FL possessing a MAP signature exhibited shorter frontline PFS, indicating a higher risk of disease progression.

           ## Clinical Implications

...	...	@@ -19,7 +19,7 @@ In their 2023 study published in Blood Advances, Russler-Germain et al. conduc
19	19	- Mutations in STAT6, TP53, IGLL5, B2M, SOCS1, and MYD88 were more common in relapsed/refractory FL or t-FL than in newly diagnosed FL.
20	20
21	21	### Mutations Associated with Progression (MAP) Signature
22		-- The MAP signature was defined as the presence of two or more mutations among the seven genes: CREBBP, STAT6, TP53, IGLL5, B2M, SOCS1, and MYD8*.
	22	+- The MAP signature was defined as the presence of two or more mutations among the seven genes: CREBBP, STAT6, TP53, IGLL5, B2M, SOCS1, and MYD88.
23	23	- Patients with newly diagnosed FL possessing a MAP signature exhibited shorter frontline PFS, indicating a higher risk of disease progression.
24	24
25	25	## Clinical Implications