BCR.md
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-BCR (Breakpoint Cluster Region Protein) is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
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+BCR (Breakpoint Cluster Region Protein) is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. This gene has some recurrent sites of mutations (hot spots).
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## Relevance tier by entity
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------------------|
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-|BL |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
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|DLBCL |1-a | aSHM target and high-confidence DLBCL gene |
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+|BL |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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