Chapuy et al. (2018)

Summary of novel genes

Entity Tier 1 genes Tier 2 genes Tier 3 genes
DLBCL 10 13 6
--- config: sankey: showValues: true linkColor: target width: 600 height: 300 nodeAlignment: right prefix: '(' suffix: ' genes)' --- sankey-beta This study, New Tier 1, 10 New Tier 1, DLBCL Tier 1, 10 This study, New Tier 2, 13 New Tier 2, DLBCL Tier 2, 13 This study, New Tier 3, 6 New Tier 3, DLBCL Tier 3, 6 All other DLBCL studies, DLBCL Tier 1, 115 All other DLBCL studies, DLBCL Tier 2, 197 All other DLBCL studies, DLBCL Tier 3, 381

Novel genes reported in this study

Tier 1

New gene DLBCL tier Average variant quality QC outcome
EEF1A1 1
HIST1H1B 1
HIST1H2AM 1
HIST2H2BE 1
HLA-C 1
HVCN1 1
LTB 1
POU2AF1 1
SIN3A 1
ZC3H12A 1

Tier 2

New gene DLBCL tier Average variant quality QC outcome
BCL11A 2
COQ7 2 ★ ★ ★ ☆ ☆ PASS
CRIP1 2 ★ ★ ★ ☆ ☆ PASS
DOCK1 2 ★ ★ ★ ☆ ☆ PASS
GABRA2 2
HLA-DMA 2
IGLL5 2
IL6 2 ★ ★ ★ ☆ ☆ PASS
LYN 2 ★ ★ ★ ★ ☆ PASS
NAV1 2
PRPS1 2 ★ ★ ★ ★ ☆ PASS
TLR2 2 ★ ★ ★ ★ ☆ PASS
ZNF423 2 ★ ★ ★ ☆ ☆ PASS

Tier 3

New gene DLBCL tier Average variant quality QC outcome
CCL4 3 ☆ ☆ ☆ ☆ ☆ FAIL
FUT5 3 ★ ☆ ☆ ☆ ☆ FAIL
NANOG 3 ☆ ☆ ☆ ☆ ☆ FAIL
NLRP8 3 ★ ★ ☆ ☆ ☆ FAIL
PDE4DIP 3 ★ ★ ☆ ☆ ☆ FAIL
RAD9A 3 ☆ ☆ ☆ ☆ ☆ FAIL

Details

Chapuy, Bjoern, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov, Robert A. Redd, Mike S. Lawrence, et al. 2018. “Molecular Subtypes of Diffuse Large B Cell Lymphoma Are Associated with Distinct Pathogenic Mechanisms and Outcomes.” Nature Medicine 24 (5): 679–90. https://doi.org/10.1038/s41591-018-0016-8.

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