Hübschmann et al. (2021)

Summary of novel genes

Entity Tier 1 genes Tier 2 genes Tier 3 genes
FL 2 16 0
DLBCL 4 20 3
--- config: sankey: showValues: true linkColor: target width: 600 height: 300 nodeAlignment: right prefix: '(' suffix: ' genes)' --- sankey-beta This study, New Tier 1, 4 New Tier 1, DLBCL Tier 1, 4 This study, New Tier 2, 20 New Tier 2, DLBCL Tier 2, 20 This study, New Tier 3, 3 New Tier 3, DLBCL Tier 3, 3 All other DLBCL studies, DLBCL Tier 1, 121 All other DLBCL studies, DLBCL Tier 2, 190 All other DLBCL studies, DLBCL Tier 3, 384

Novel genes reported in this study

Tier 1

New gene FL tier DLBCL tier Average variant quality QC outcome
ACTG1 2 1
EEF1A1 1 1
HLA-DMB 1
MEF2C 2 1
VMA21 1

Tier 2

New gene FL tier DLBCL tier Average variant quality QC outcome
ADAMTS1 2 ★ ★ ★ ☆ ☆ PASS
ANKRD12 2 ★ ★ ★ ☆ ☆ PASS
ATP6V1A 2
CADPS2 2 ★ ★ ★ ★ ☆ PASS
CDC42BPB 2
CNOT2 2 ★ ★ ★ ★ ☆ PASS
CPNE8 2
DHX15 2
DHX16 2 ★ ★ ★ ★ ☆ PASS
DNM2 2 ★ ★ ★ ☆ ☆ PASS
FZR1 2
IKBKE 2 ★ ★ ★ ★ ☆ PASS
IRF1 2 ★ ★ ★ ☆ ☆ PASS
JUP 2
LAPTM5 2 2 ★ ★ ★ ★ ☆ PASS
LRP12 2 ★ ★ ★ ☆ ☆ PASS
MGEA5 2
MYCBP2 2
PDS5B 2 2 ★ ★ ★ ★ ☆ PASS
PNPO 2 ★ ★ ★ ☆ ☆ PASS
PPP4C 2
PRKDC 2 2
RAC2 2 ★ ★ ★ ☆ ☆ PASS
RBM6 2
SIAH2 2 ★ ★ ★ ☆ ☆ PASS
SLC34A2 2 ★ ★ ★ ☆ ☆ PASS
TPP1 2
TRAF6 2 ★ ★ ★ ☆ ☆ PASS
UNC5B 2 ★ ★ ★ ☆ ☆ PASS
WNK1 2 ★ ★ ★ ☆ ☆ PASS
ZNF217 2 ★ ★ ★ ☆ ☆ PASS

Tier 3

New gene FL tier DLBCL tier Average variant quality QC outcome
GAK 3 ★ ★ ☆ ☆ ☆ FAIL
HLA-DQA1 3 ★ ★ ☆ ☆ ☆ FAIL
NR2F2 3 ★ ★ ☆ ☆ ☆ FAIL

Details

Hübschmann, Daniel, Kortine Kleinheinz, Rabea Wagener, Stephan H. Bernhart, Cristina López, Umut H. Toprak, Stephanie Sungalee, et al. 2021. “Mutational Mechanisms Shaping the Coding and Noncoding Genome of Germinal Center Derived B-cell Lymphomas.” Leukemia 35 (7): 2002–16. https://doi.org/10.1038/s41375-021-01251-z.

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