Love et al. (2012)

Summary of novel genes

Entity Tier 1 genes Tier 2 genes Tier 3 genes
BL 5 7 48
--- config: sankey: showValues: true linkColor: target width: 600 height: 300 nodeAlignment: right prefix: '(' suffix: ' genes)' --- sankey-beta This study, New Tier 1, 5 New Tier 1, BL Tier 1, 5 This study, New Tier 2, 7 New Tier 2, BL Tier 2, 7 This study, New Tier 3, 48 New Tier 3, BL Tier 3, 48 All other BL studies, BL Tier 1, 27 All other BL studies, BL Tier 2, 65 All other BL studies, BL Tier 3, 22

Novel genes reported in this study

Tier 1

New gene BL tier Average variant quality QC outcome
ARID1A 1
BCL6 1 ★ ★ ★ ★ ☆ PASS
CREBBP 1 ★ ★ ★ ★ ☆ PASS
GNA13 1
PTEN 1

Tier 2

New gene BL tier Average variant quality QC outcome
CARD4 2 ★ ★ ★ ★ ☆ PASS
CDC73 2 ★ ★ ★ ☆ ☆ PASS
EZH2 2 ★ ★ ★ ★ ★ PASS
GGTLA4 2 ★ ★ ★ ★ ☆ PASS
NBEAL1 2 ★ ★ ★ ★ ☆ PASS
P2RY2 2 ★ ★ ★ ★ ☆ PASS
RANBP6 2 ★ ★ ★ ★ ★ PASS

Tier 3

New gene BL tier Average variant quality QC outcome
ACAD9 3 ★ ☆ ☆ ☆ ☆ FAIL
ACE 3 ★ ☆ ☆ ☆ ☆ FAIL
ATP2C2 3 ★ ★ ☆ ☆ ☆ FAIL
BRAF 3 ★ ☆ ☆ ☆ ☆ FAIL
BRD4 3 ★ ☆ ☆ ☆ ☆ FAIL
BTG2 3 ★ ☆ ☆ ☆ ☆ FAIL
C6orf27 3 Germline FAIL
CAD 3 ★ ☆ ☆ ☆ ☆ FAIL
CCT6B 3 Germline FAIL
CDH17 3 ★ ☆ ☆ ☆ ☆ FAIL
COL4A2 3 ★ ☆ ☆ ☆ ☆ FAIL
CYB5D1 3 ★ ★ ☆ ☆ ☆ FAIL
CYP4F22 3 ★ ☆ ☆ ☆ ☆ FAIL
DLGAP1 3 ★ ☆ ☆ ☆ ☆ FAIL
DTX1 3 ★ ☆ ☆ ☆ ☆ FAIL
EIF2C4 3 ★ ☆ ☆ ☆ ☆ FAIL
EML2 3 ★ ☆ ☆ ☆ ☆ FAIL
ENTPD3 3 ★ ★ ☆ ☆ ☆ FAIL
EPHB2 3 ★ ★ ☆ ☆ ☆ FAIL
FAM129B 3 ★ ★ ☆ ☆ ☆ FAIL
FGFR3 3 ★ ☆ ☆ ☆ ☆ FAIL
FTCD 3 Germline FAIL
GRIK5 3 ★ ☆ ☆ ☆ ☆ FAIL
ICK 3 ★ ☆ ☆ ☆ ☆ FAIL
ITPR3 3 ★ ☆ ☆ ☆ ☆ FAIL
KIFC3 3 ★ ☆ ☆ ☆ ☆ FAIL
MAP3K6 3 ★ ☆ ☆ ☆ ☆ FAIL
MYH10 3 ★ ☆ ☆ ☆ ☆ FAIL
NOTCH1 3 ★ ☆ ☆ ☆ ☆ FAIL
NRXN2 3 ★ ☆ ☆ ☆ ☆ FAIL
PC 3 ★ ☆ ☆ ☆ ☆ FAIL
POLRMT 3 ★ ☆ ☆ ☆ ☆ FAIL
POR 3 ★ ☆ ☆ ☆ ☆ FAIL
PRSS22 3 ★ ☆ ☆ ☆ ☆ FAIL
PTPRN 3 ★ ☆ ☆ ☆ ☆ FAIL
RBP3 3 ★ ☆ ☆ ☆ ☆ FAIL
RET 3 ★ ☆ ☆ ☆ ☆ FAIL
SALL3 3 ★ ★ ☆ ☆ ☆ FAIL
SAPS2 3 ★ ☆ ☆ ☆ ☆ FAIL
SBF1 3 ★ ★ ☆ ☆ ☆ FAIL
SF3B1 3 ★ ★ ★ ★ ☆ FAIL
SHANK1 3 ★ ☆ ☆ ☆ ☆ FAIL
SLC29A2 3 ★ ☆ ☆ ☆ ☆ FAIL
SYNGAP1 3 ★ ☆ ☆ ☆ ☆ FAIL
TBC1D9B 3 ★ ☆ ☆ ☆ ☆ FAIL
TIGD6 3 ★ ☆ ☆ ☆ ☆ FAIL
TPST2 3 ☆ ☆ ☆ ☆ ☆ FAIL
ZNF229 3 Germline FAIL

Details

Love, Cassandra, Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Rodney Miles, Kristy L. Richards, et al. 2012. “The Genetic Landscape of Mutations in Burkitt Lymphoma.” Nature Genetics 44 (12): 1321–25. https://doi.org/10.1038/ng.2468.

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