Summary of novel genes

Entity Tier 1 genes Tier 2 genes Tier 3 genes
DLBCL 9 23 7
--- config: sankey: showValues: true linkColor: target width: 600 height: 300 nodeAlignment: right prefix: '(' suffix: ' genes)' --- sankey-beta This study, New Tier 1, 9 New Tier 1, DLBCL Tier 1, 9 This study, New Tier 2, 23 New Tier 2, DLBCL Tier 2, 23 This study, New Tier 3, 7 New Tier 3, DLBCL Tier 3, 7 All other DLBCL studies, DLBCL Tier 1, 116 All other DLBCL studies, DLBCL Tier 2, 187 All other DLBCL studies, DLBCL Tier 3, 380

Novel genes reported in this study

Tier 1

New gene DLBCL tier Average variant quality QC outcome
CD83 1
CDKN2A 1
GNAI2 1
HIST1H1D 1
HIST1H2AC 1
MPEG1 1
RB1 1
TAF1 1
ZNF608 1

Tier 2

New gene DLBCL tier Average variant quality QC outcome
ABI3BP 2 ★ ★ ★ ☆ ☆ PASS
ARAP2 2
CDH9 2 ★ ★ ★ ☆ ☆ PASS
CNTNAP5 2 ★ ★ ★ ★ ☆ PASS
DNAH5 2 ★ ★ ★ ★ ☆ PASS
DSEL 2
DSG4 2 ★ ★ ★ ☆ ☆ PASS
FAT4 2 ★ ★ ★ ☆ ☆ PASS
HDAC7 2 ★ ★ ★ ☆ ☆ PASS
HIST1H2AG 2 ★ ★ ★ ☆ ☆ PASS
IFNGR1 2 ★ ★ ★ ★ ☆ PASS
MPDZ 2 ★ ★ ★ ★ ☆ PASS
NLRP5 2 ★ ★ ★ ☆ ☆ PASS
ODZ2 2 ★ ★ ★ ☆ ☆ PASS
P2RX5 2 ★ ★ ★ ☆ ☆ PASS
PASK 2 ★ ★ ★ ★ ☆ PASS
PCDHB11 2 ★ ★ ★ ☆ ☆ PASS
PDS5B 2 ★ ★ ★ ★ ☆ PASS
PRKCB 2 ★ ★ ★ ★ ☆ PASS
SAMD9L 2 ★ ★ ★ ☆ ☆ PASS
SRRM2 2 ★ ★ ★ ☆ ☆ PASS
SYPL1 2 ★ ★ ★ ☆ ☆ PASS
WDFY3 2 ★ ★ ★ ★ ☆ PASS

Tier 3

New gene DLBCL tier Average variant quality QC outcome
FAM38B 3 ★ ★ ☆ ☆ ☆ FAIL
FNDC1 3 ★ ★ ☆ ☆ ☆ FAIL
IER2 3 ★ ☆ ☆ ☆ ☆ FAIL
PKD1 3 ★ ★ ☆ ☆ ☆ FAIL
POGZ 3 ★ ★ ☆ ☆ ☆ FAIL
PTPN23 3 ★ ★ ☆ ☆ ☆ FAIL
SARM1 3 ★ ★ ☆ ☆ ☆ FAIL

Details

Morin, Ryan D., Karen Mungall, Erin Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, et al. 2013. “Mutational and Structural Analysis of Diffuse Large B-cell Lymphoma Using Whole-Genome Sequencing.” Blood 122 (7): 1256–65. https://doi.org/10.1182/blood-2013-02-483727.

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