Reddy et al. (2017)

Summary of novel genes

Entity Tier 1 genes Tier 2 genes Tier 3 genes
DLBCL 13 28 26
--- config: sankey: showValues: true linkColor: target width: 600 height: 300 nodeAlignment: right prefix: '(' suffix: ' genes)' --- sankey-beta This study, New Tier 1, 13 New Tier 1, DLBCL Tier 1, 13 This study, New Tier 2, 28 New Tier 2, DLBCL Tier 2, 28 This study, New Tier 3, 26 New Tier 3, DLBCL Tier 3, 26 All other DLBCL studies, DLBCL Tier 1, 112 All other DLBCL studies, DLBCL Tier 2, 182 All other DLBCL studies, DLBCL Tier 3, 361

Novel genes reported in this study

Tier 1

New gene DLBCL tier Average variant quality QC outcome
ATM 1
BIRC6 1
DDX3X 1
HNRNPU 1
MGA 1
PIM2 1
PTEN 1
PTPN6 1 ★ ★ ★ ☆ ☆ PASS
SF3B1 1
SMARCA4 1
TMSB4X 1
TOX 1
ZNF292 1

Tier 2

New gene DLBCL tier Average variant quality QC outcome
ARID5B 2 ★ ★ ★ ★ ☆ PASS
ATR 2 ★ ★ ★ ☆ ☆ PASS
BRINP3 2 ★ ★ ★ ☆ ☆ PASS
CASP8 2
CD22 2 ★ ★ ★ ☆ ☆ PASS
FOXP1 2 ★ ★ ★ ☆ ☆ PASS
FUBP1 2 ★ ★ ★ ☆ ☆ PASS
GOLGA5 2 ★ ★ ★ ☆ ☆ PASS
HNRNPD 2
IKBKB 2 ★ ★ ★ ☆ ☆ PASS
IL16 2
INO80 2
JAK1 2
JAK3 2
KCMF1 2 ★ ★ ★ ☆ ☆ PASS
MAGT1 2 ★ ★ ★ ☆ ☆ PASS
MCL1 2 ★ ★ ★ ☆ ☆ PASS
MECOM 2 ★ ★ ★ ☆ ☆ PASS
MET 2 ★ ★ ★ ☆ ☆ PASS
MSH6 2 ★ ★ ★ ☆ ☆ PASS
SETD5 2 ★ ★ ★ ☆ ☆ PASS
STAT5B 2
TCL1A 2
TGFBR2 2 ★ ★ ★ ☆ ☆ PASS
TIPARP 2 ★ ★ ★ ☆ ☆ PASS
YY1 2 ★ ★ ★ ☆ ☆ PASS
ZEB2 2
ZFX 2 ★ ★ ★ ☆ ☆ PASS

Tier 3

New gene DLBCL tier Average variant quality QC outcome
ARID1B 3 ★ ★ ☆ ☆ ☆ FAIL
CBLB 3 ★ ★ ☆ ☆ ☆ FAIL
CDC73 3 ★ ★ ☆ ☆ ☆ FAIL
CDH8 3 ★ ★ ☆ ☆ ☆ FAIL
CHD1 3 ★ ★ ☆ ☆ ☆ FAIL
CHST2 3 ★ ★ ☆ ☆ ☆ FAIL
DCAF6 3 ★ ★ ☆ ☆ ☆ FAIL
DICER1 3 ★ ★ ☆ ☆ ☆ FAIL
DNMT3A 3 ★ ☆ ☆ ☆ ☆ FAIL
GNAS 3 ★ ★ ☆ ☆ ☆ FAIL
HRAS 3 ★ ★ ☆ ☆ ☆ FAIL
LIN54 3 ★ ★ ☆ ☆ ☆ FAIL
MAP4K4 3 ★ ★ ☆ ☆ ☆ FAIL
MARK1 3 ★ ☆ ☆ ☆ ☆ FAIL
MSH2 3 ★ ★ ☆ ☆ ☆ FAIL
MYB 3 ★ ★ ☆ ☆ ☆ FAIL
NCOR1 3 ★ ★ ☆ ☆ ☆ FAIL
NFKB2 3 ★ ★ ☆ ☆ ☆ FAIL
PHF6 3 ★ ★ ☆ ☆ ☆ FAIL
PTPRK 3 ★ ★ ☆ ☆ ☆ FAIL
RARA 3 ★ ☆ ☆ ☆ ☆ FAIL
RUNX1 3 ★ ★ ☆ ☆ ☆ FAIL
SYK 3 ★ ★ ☆ ☆ ☆ FAIL
WAC 3 ★ ★ ☆ ☆ ☆ FAIL
ZBTB7A 3 ★ ☆ ☆ ☆ ☆ FAIL
ZFAT 3 ★ ★ ☆ ☆ ☆ FAIL

Details

Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. “Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.” Cell 171 (2): 481–494.e15.

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