Reddy et al. (2017)

Summary of novel genes

Entity Tier 1 genes Tier 2 genes
DLBCL 7 53
--- config: sankey: showValues: true linkColor: target width: 600 height: 300 nodeAlignment: right prefix: '(' suffix: ' genes)' --- sankey-beta This study, New Tier 1, 7 New Tier 1, DLBCL Tier 1, 7 This study, New Tier 2, 53 New Tier 2, DLBCL Tier 2, 53 All other DLBCL studies, DLBCL Tier 1, 121 All other DLBCL studies, DLBCL Tier 2, 145

Novel genes reported in this study

Tier 1

New gene DLBCL tier
ATM 1
BIRC6 1
HIST1H2BC 1
HNRNPU 1
SETD1B 1
TOX 1
UBE2A 1

Tier 2

New gene DLBCL tier Rating of reviewed variants
ANKRD17 2 ★ ★ ★ ☆ ☆
ARID1B 2 ★ ★ ☆ ☆ ☆
ARID5B 2 ★ ★ ★ ★ ☆
ATR 2 ★ ★ ★ ☆ ☆
BRINP3 2 ★ ★ ★ ☆ ☆
BTBD3 2 ★ ★ ★ ★ ☆
CASP8 2 ★ ★ ★ ☆ ☆
CBLB 2 ★ ★ ☆ ☆ ☆
CD22 2 ★ ★ ★ ☆ ☆
CDC73 2 ★ ★ ☆ ☆ ☆
CHD1 2 ★ ★ ☆ ☆ ☆
CHD8 2 ★ ★ ☆ ☆ ☆
CHST2 2 ★ ★ ☆ ☆ ☆
DCAF6 2 ★ ★ ☆ ☆ ☆
DDX10 2 ★ ★ ☆ ☆ ☆
DICER1 2 ★ ★ ☆ ☆ ☆
DNMT3A 2
FOXP1 2
FUBP1 2
GNAS 2
GOLGA5 2
HRAS 2
IKBKB 2
JUNB 2
KCMF1 2
LIN54 2
MAGT1 2
MAP4K4 2
MARK1 2
MCL1 2
MECOM 2
MET 2
MSH2 2
MSH6 2
MYB 2
NCOR1 2
NF1 2
NFKB2 2
PHF6 2
PIK3CD 2
PTPN6 2
PTPRK 2
RARA 2
RUNX1 2
SETD5 2
SYK 2
TGFBR2 2
TIPARP 2
WAC 2
YY1 2
ZBTB7A 2
ZFAT 2
ZFX 2

Details

Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. “Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.” Cell 171 (2): 481–494.e15.

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