Zhang et al. (2013)

Summary of novel genes

Entity Tier 1 genes Tier 2 genes Tier 3 genes
DLBCL 15 10 275
--- config: sankey: showValues: true linkColor: target width: 600 height: 300 nodeAlignment: right prefix: '(' suffix: ' genes)' --- sankey-beta This study, New Tier 1, 15 New Tier 1, DLBCL Tier 1, 15 This study, New Tier 2, 10 New Tier 2, DLBCL Tier 2, 10 This study, New Tier 3, 275 New Tier 3, DLBCL Tier 3, 275 All other DLBCL studies, DLBCL Tier 1, 112 All other DLBCL studies, DLBCL Tier 2, 166 All other DLBCL studies, DLBCL Tier 3, 114

Novel genes reported in this study

Tier 1

New gene DLBCL tier Average variant quality QC outcome
ARID1A 1
BCL7A 1
DTX1 1
FBXW7 1
HIST1H2BK 1
KLHL14 1
KMT2C 1
MGA 1
MTOR 1
NOTCH2 1
OSBPL10 1
RHOA 1
TRRAP 1
ZNF292 1
ZNF608 1

Tier 2

New gene DLBCL tier Average variant quality QC outcome
BTBD3 2 ★ ★ ★ ★ ☆ PASS
INO80 2
JAK1 2
JAK3 2
PIK3R1 2
SETD2 2
SMEK1 2
STAT5B 2
UBR5 2
ZEB2 2

Tier 3

New gene DLBCL tier Average variant quality QC outcome
ABCA3 3
ABCA4 3
ACE 3
ACSM3 3
ACSS2 3
ACSS3 3
ACTN1 3
ADAM2 3
ADAMTS15 3
ADH7 3
AFAP1L2 3
AHR 3
AKAP9 3
ALAS1 3
ALDH1L2 3
AMAC1 3
AMIGO3 3
AMPH 3
ANK2 3
ANKRD17 3 ★ ★ ★ ☆ ☆ FAIL
ANKRD44 3
ANTXR1 3
AP1G2 3
APBB1 3
APC 3
APOA5 3
APP 3
ATIC 3
ATP10A 3
ATP1A2 3
ATP2A3 3
B4GALNT2 3
BAZ1A 3
BCAT2 3
BLM 3
BMPR1A 3
BRCA2 3
BRD4 3
BSCL2 3
BTAF1 3
C9 3
CAD 3
CAPN5 3
CAPN7 3
CCDC132 3
CCDC46 3
CCDC97 3
CCNF 3
CDC123 3
CDH10 3
CDH7 3
CDK3 3
CECR1 3
CELSR2 3
CHD3 3
CHRM5 3
CIC 3
CNGA4 3
CNOT6 3
CNP 3
CNTN6 3
COL5A2 3
CORO2A 3
CORO7 3
CRELD2 3
CRTC3 3
CST7 3
CTNNA3 3
CYP24A1 3
CYP2C18 3
DDB1 3
DDX10 3 ★ ★ ☆ ☆ ☆ FAIL
DIAPH3 3
DIP2B 3
DLGAP1 3
DMXL1 3
DOCK2 3
DOLK 3
DSC2 3
DSCAML1 3
DSG2 3
DSP 3
DUOXA2 3
DUPD1 3
DYNC1H1 3
DYNC1I1 3
ECGF1 3
EPHA3 3
EPHA5 3
EPHA7 3
ERBB3 3
ERN2 3
ETNPPL 3
EXTL3 3
FAM62C 3
FANCD2 3
FGD3 3
FGFR1 3
FIGN 3
FLNC 3
FMO2 3
FRMPD1 3
GABRG1 3
GCN1L1 3
GJA8 3
GJB4 3
GOPC 3
GPD2 3
GPR133 3
GPR15 3
GREM2 3
GRIA2 3
GRM5 3
H6PD 3
HACE1 3
HCK 3
HIPK3 3
HIST1H4I 3
HK3 3
HNRNPR 3
HSF2 3
IDH1 3
INSC 3
INTS6 3
IQGAP1 3
IQUB 3
ITGA2 3
ITGA8 3
ITGB3 3
JAG1 3
JAKMIP2 3
KCNA3 3
KCNAB3 3
KCNJ6 3
KCNT2 3
KDR 3
KIF21B 3
KIT 3
KLB 3
KLC3 3
KLF4 3
KRT6A 3
LEPREL1 3
LIFR 3
LILRA2 3
LIN7C 3
LPHN2 3
LRAP 3
LRIG3 3
LRP1 3
LRP10 3
LRP1B 3
LRP3 3
LRRN3 3 ★ ★ ★ ★ ★ PASS
LYST 3
MARCHF7 3
MBL2 3
MED13L 3
MIB1 3
MN1 3
MORC2 3
MPL 3
MTMR3 3
MYL7 3
MYO5C 3
MYRIP 3
NDUFS1 3
NELL2 3
NFIB 3
NFX1 3
NGFR 3
NIPBL 3
NLGN2 3
NLRP7 3
NPHP1 3
NPY2R 3
NRXN2 3
NSD1 3
NSD2 3
ONECUT1 3
PADI1 3
PAPPA2 3
PBX1 3
PCCB 3
PCDE1C 3
PCDH7 3
PCDHB1 3
PCDHB15 3
PCDHB3 3
PCDHB5 3
PCDHGA2 3
PDE1C 3
PDGFRA 3
PDIA2 3
PDZRN3 3
PDZRN4 3
PIK3CD 3 ★ ★ ☆ ☆ ☆ FAIL
PLA2G4B 3
PLEKHA7 3
PNLIPRP1 3
PNPT1 3
POLE 3
PPARGC1A 3
PPWD1 3
PRDM16 3
PRKCB1 3
PRKCQ 3
PROS1 3
PRSS7 3
PTPN14 3
PTPRF 3
PTPRT 3
PXK 3
RAB3GAP1 3
RAPGEF2 3
RBM15B 3
RELN 3
RFC1 3
RGS1 3
ROR2 3
RSL1D1 3
RUNDC1 3
RYR1 3
SAPS3 3
SCYL1 3
SEMA3A 3
SEMA3D 3
SEMA5A 3
SERINC2 3
SH3PXD2B 3
SHMT2 3
SIGLEC10 3
SLC16A7 3
SLC4A8 3
SLC5A1 3
SLC9A5 3
SOX6 3
SPEG 3
SPTBN1 3
ST8SIA3 3
SULF2 3
TAF1L 3
TAF4B 3
THBS4 3
TIMM50 3
TLN2 3
TMC1 3
TMEM161A 3
TMEM16E 3
TMEM63A 3
TPRKB 3
TRIM37 3
TRIP11 3
TSC2 3
TSHZ2 3
UHRF1BP1L 3
UNC13B 3
UQCRC1 3
VPS13A 3
WDR65 3
WDR66 3
WDR67 3
WIF1 3
WNK4 3
WT1 3
XDH 3
ZIC4 3
ZNF354A 3
ZNF366 3
ZNF439 3
ZNF474 3
ZNF700 3
ZNF790 3
ZNF91 3
ZP1 3

Details

Zhang, Jenny, Vladimir Grubor, Cassandra L Love, Anjishnu Banerjee, Kristy L Richards, Piotr A Mieczkowski, Cherie Dunphy, et al. 2013. “Genetic Heterogeneity of Diffuse Large B-cell Lymphoma.” Proceedings of the National Academy of Sciences of the United States of America 110: 1398–1403. https://doi.org/10.1073/pnas.1205299110.

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