TP53 Hotspots

Chromosome Coordinate (hg19) DLBCL FL BL HGVSp
17 7577538,7577539 44 5 26 R248Q
17 7577538,7577539 44 5 26 R248W
17 7577120,7577121 32 5 28 R273C
17 7577120,7577121 32 5 28 R273H
17 7577120,7577121 32 5 28 R273L
17 7577120,7577121 32 5 28 R273G
17 7577120,7577121 32 5 28 R273S
17 7578406 32 3 11 R175H
17 7577580,7577581,7577579 17 3 8 Y234H
17 7577580,7577581,7577579 17 3 8 Y234N
17 7577580,7577581,7577579 17 3 8 Y234S
17 7577580,7577581,7577579 17 3 8 Y234C
17 7577580,7577581,7577579 17 3 8 Y234*
17 7577580,7577581,7577579 17 3 8 Y234D
17 7577547,7577548 15 0 10 G245S
17 7577547,7577548 15 0 10 G245D
17 7577547,7577548 15 0 10 G245C
17 7577547,7577548 15 0 10 G245R
17 7577547,7577548 15 0 10 G245V
17 7577093,7577094 17 0 5 R282W
17 7577093,7577094 17 0 5 R282P
17 7577093,7577094 17 0 5 R282G
17 7577093,7577094 17 0 5 R282Q
17 7578402,7578403,7578404 15 0 2 C176F
17 7578402,7578403,7578404 15 0 2 C176R
17 7578402,7578403,7578404 15 0 2 C176S
17 7578402,7578403,7578404 15 0 2 C176Y
17 7578402,7578403,7578404 15 0 2 C176G
17 7578402,7578403,7578404 15 0 2 C176W
17 7578211,7578212 10 0 5 R213*
17 7578211,7578212 10 0 5 R213Q
17 7578234,7578235,7578236 11 2 2 Y205C
17 7578234,7578235,7578236 11 2 2 Y205N
17 7578234,7578235,7578236 11 2 2 Y205D
17 7578234,7578235,7578236 11 2 2 Y205H
17 7578211,7578212 10 0 5 R213G
17 7578211,7578212 10 0 5 R213L
17 7578234,7578235,7578236 11 2 2 Y205*
17 7578234,7578235,7578236 11 2 2 Y205F
17 7578234,7578235,7578236 11 2 2 Y205S
17 7577565,7577566,7577564 10 1 2 N239D
17 7577565,7577566,7577564 10 1 2 N239S
17 7577565,7577566,7577564 10 1 2 N239T
17 7577565,7577566,7577564 10 1 2 N239K
17 7578412,7578413 9 0 3 V173M
17 7577574,7577575 10 0 2 Y236C
17 7577574,7577575 10 0 2 Y236D
17 7577574,7577575 10 0 2 Y236H
17 7578412,7578413 9 0 3 V173L
17 7577574,7577575 10 0 2 Y236N
17 7578412,7578413 9 0 3 V173A
17 7578412,7578413 9 0 3 V173Efs*7
17 7578412,7578413 9 0 3 V173G
17 7577574,7577575 10 0 2 Y236S
17 7578203,7578202 7 0 3 V216M
17 7578393,7578394,7578395 7 0 3 H179R
17 7578203,7578202 7 0 3 V216L
17 7578393,7578394,7578395 7 0 3 H179L
17 7578393,7578394,7578395 7 0 3 H179Q
17 7578393,7578394,7578395 7 0 3 H179Y
17 7578203,7578202 7 0 3 V216G
17 7578262,7578263 8 0 1 R196*
17 7578262,7578263 8 0 1 R196P
17 7577550,7577551 4 2 2 G244D
17 7577559,7577560 4 1 3 S241P
17 7578525,7578526,7578527 4 1 3 C135F
17 7578442,7578443 7 0 1 Y163C
17 7578442,7578443 7 0 1 Y163D
17 7578525,7578526,7578527 4 1 3 C135Y
17 7577559,7577560 4 1 3 S241A
17 7577559,7577560 4 1 3 S241F
17 7578525,7578526,7578527 4 1 3 C135G
17 7578525,7578526,7578527 4 1 3 C135R
17 7578525,7578526,7578527 4 1 3 C135W
17 7577550,7577551 4 2 2 G244R
17 7577550,7577551 4 2 2 G244S
17 7577550,7577551 4 2 2 G244V
17 7578442,7578443 7 0 1 Y163H
17 7578442,7578443 7 0 1 Y163N
17 7578508,7578509 4 1 2 C141Y
17 7578457 2 0 5 R158H
17 7577556,7577557 5 1 1 C242S
17 7577556,7577557 5 1 1 C242R
17 7577556,7577557 5 1 1 C242Y
17 7578508,7578509 4 1 2 C141G
17 7578457 2 0 5 R158L
17 7578553 3 0 3 Y126C
17 7577535,7577536 3 0 3 R249G
17 7578204,7578205,7578206 2 0 4 S215R
17 7577567,7577568,7577569 4 0 2 C238Y
17 7578460,7578461 3 2 1 V157F
17 7578271,7578272 3 2 1 H193L
17 7578271,7578272 3 2 1 H193R
17 7577567,7577568,7577569 4 0 2 C238G
17 7577567,7577568,7577569 4 0 2 C238S
17 7577567,7577568,7577569 4 0 2 C238W
17 7578271,7578272 3 2 1 H193D
17 7578271,7578272 3 2 1 H193Y
17 7577535,7577536 3 0 3 R249T
17 7578204,7578205,7578206 2 0 4 S215N
17 7578204,7578205,7578206 2 0 4 S215T
17 7578460,7578461 3 2 1 V157A
17 7578460,7578461 3 2 1 V157D
17 7578460,7578461 3 2 1 V157G
17 7578449 2 1 2 A161T
17 7579312,7579313 2 0 3 T125=
17 7578517,7578518 4 0 1 A138P
17 7578517,7578518 4 0 1 A138V
17 7578534,7578535,7578536 3 0 2 K132Q
17 7577106,7577105 4 0 1 P278T
17 7577099,7577100 2 0 3 R280K
17 7579312,7579313 2 0 3 T125M
17 7577117,7577118 5 0 0 V274L
17 7578517,7578518 4 0 1 A138Cfs*27
17 7578449 2 1 2 A161P
17 7578534,7578535,7578536 3 0 2 K132E
17 7578534,7578535,7578536 3 0 2 K132R
17 7578534,7578535,7578536 3 0 2 K132T
17 7577106,7577105 4 0 1 P278A
17 7577106,7577105 4 0 1 P278L
17 7577106,7577105 4 0 1 P278R
17 7577099,7577100 2 0 3 R280G
17 7577099,7577100 2 0 3 R280I
17 7577099,7577100 2 0 3 R280T
17 7577117,7577118 5 0 0 V274A
17 7577117,7577118 5 0 0 V274F
17 7577117,7577118 5 0 0 V274G
17 7578265 3 0 1 I195T
17 7578389,7578388 3 0 1 R181C
17 7577095,7577096,7577097 1 1 2 D281G
17 7577586,7577587 3 0 1 I232T
17 7578280,7578281 2 0 2 P190L
17 7578415,7578416 2 0 2 V172D
17 7577095,7577096,7577097 1 1 2 D281E
17 7577095,7577096,7577097 1 1 2 D281N
17 7578265 3 0 1 I195N
17 7577586,7577587 3 0 1 I232F
17 7577586,7577587 3 0 1 I232N
17 7577543,7577544,7577545 2 0 2 M246I
17 7577543,7577544,7577545 2 0 2 M246K
17 7577543,7577544,7577545 2 0 2 M246T
17 7577543,7577544,7577545 2 0 2 M246V
17 7578280,7578281 2 0 2 P190Lfs*57
17 7578280,7578281 2 0 2 P190T
17 7578389,7578388 3 0 1 R181H
17 7578415,7578416 2 0 2 V172A
17 7578415,7578416 2 0 2 V172F
17 7577085 3 0 0 E285K
17 7578538 3 0 0 N131I
17 7577082,7577081 2 1 0 E286G
17 7579328,7579329 2 0 1 K120R
17 7577124,7577123 1 0 2 V272M
17 7577082,7577081 2 1 0 E286K
17 7577520 2 0 1 I254D
17 7577520 2 0 1 I254N
17 7577520 2 0 1 I254S
17 7579328,7579329 2 0 1 K120E
17 7578532 2 1 0 M133Ifs*17
17 7578532 2 1 0 M133K
17 7578532 2 1 0 M133T
17 7577124,7577123 1 0 2 V272A
17 7578454 1 0 1 A159V
17 7577113,7577114 1 0 1 C275W
17 7577113,7577114 1 0 1 C275Y
17 7577541 0 0 2 N247I
17 7577541 0 0 2 N247T
17 7577108 1 0 0 C277Y
nan nan 1 0 0 E204_Y205insLE
17 7578427 1 0 0 H168R
nan nan 0 1 0 HY233QH
17 7578513 0 0 1 K139N
17 7578542 0 0 1 L130F
17 7578268 1 0 0 L194R
nan nan 1 0 0 L252_I254del
nan nan 0 0 1 P152Afs*14
17 7577532 0 0 1 P250L
17 7578463 0 0 1 R156H
nan nan 1 0 0 R283Gfs*68
17 7577563 1 0 0 S240G
nan nan 1 0 0 T155_R156dup
17 7577524 1 0 0 T253P
17 7578502 1 0 0 V143A
17 7578241 0 1 0 V203A
nan nan 1 0 0 X125_splice

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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