Table of Contents

Overview

Relevance tier by entity

test

Test

Entity Tier Description
DLBCL 1 high-confidence DLBCL gene
FL 1 high-confidence FL gene
PMBL 2 relevance in PMBL/cHL/GZL not firmly established
BL 2 relevance in BL not firmly established

Warnings

may not exist

Mutation incidence from meta-analysis

sub headings per file here unless there is just one

DLBCL

Cannot include /templates/tables/DLBCL_BCL2.md - does not exist yet

FL

Cannot include /templates/tables/FL_BCL2.md - does not exist yet

BL

Cannot include /templates/tables/BL_BCL2.md - does not exist yet

Mutation pattern and selective pressure estimates

Cannot include /templates/tables/dnds_BCL2.md - does not exist yet

aSHM regions

section will only exist for certain genes

chr_name hg19_start hg19_end region regulatory_comment
chr6 90981034 91016134 TSS NA

Hotspots

section will only exist for certain genes

Browse mutations

Protein

View coding variants in ProteinPaint hg19 or hg38

Genome

View all variants in GenomePaint hg19 or hg38

Expression

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 1992-01-01 : Tanaka : DLBCL 2011-07-27 : Morin : FL 2021-04-01 : Sarkozy : PMBL 2022-07-06 : Burkhardt : BL

References

1.
Bal E, Kumar R, Hadigol M, Holmes AB, Hilton LK, Loh JW, Dreval K, Wong JCH, Vlasevska S, Corinaldesi C, Soni RK, Basso K, Morin RD, Khiabanian H, Pasqualucci L, Dalla-Favera R. Super-enhancer hypermutation alters oncogene expression in B cell lymphoma. Nature. 2022 Jul;607(7920):808–815. PMCID: PMC9583699
2.
Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584
3.
Sarkozy C, Hung SS, Chavez EA, Duns G, Takata K, Chong LC, Aoki T, Jiang A, Miyata-Takata T, Telenius A, Slack GW, Molina TJ, Ben-Neriah S, Farinha P, Dartigues P, Damotte D, Mottok A, Salles GA, Casasnovas RO, Savage KJ, Laurent C, Scott DW, Traverse-Glehen A, Steidl C. Mutational landscape of gray zone lymphoma. Blood. 2021 Apr 1;137(13):1765–1776.
4.
Tanaka S, Louie DC, Kant JA, Reed JC. Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin’s lymphomas. Blood. 1992 Jan 1;79(1):229–237.

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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