[CD83]
Mutation tier
| Entity | Tier |
|---|---|
| BL | 2 |
| DLBCL | 1 |
| FL | 1 |
Mutation incidence
| Entity | study | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 1.15 |
| BL | Thomas cohort | 1.70 |
| BL | Panea cohort | NA |
| DLBCL | GAMBL genomes | 4.50 |
| DLBCL | Schmitz cohort | 5.70 |
| DLBCL | Reddy cohort | 5.80 |
| DLBCL | Chapuy cohort | 7.30 |
| FL | GAMBL genomes | 1.85 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 4.396 | 0.000 |
| DLBCL | Yes | No | 4.794 | 14.227 |
| FL | Yes | No | 0.000 | 25.732 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr6 | 14118026 | 14120025 | TSS | active_promoter-strong_enhancer |
[!NOTE] First described in BL in 2019 by Panea RI. First described in DLBCL in 2018 by Schmitz R. First described in FL in 2023 by Russler-Germain DA
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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