| Year | Focus | Sequencing Method | Novel genes | Tier 1 (%) | Example gene | Study |
|---|---|---|---|---|---|---|
| 1992 | BL | Sanger | 1 | 1 (100.0) | MYC | Johnston and Carroll (1992) |
| 1992 | DLBCL | Sanger | 1 | 1 (100.0) | BCL2 | Tanaka et al. (1992) |
| 2001 | DLBCL | Sanger | 4 | 2 (50.0) | MYC | (pasqualucciHypermutationMultipleProtooncogenes2001a?) |
| 2004 | BL | Sanger | 1 | 1 (100.0) | TP53 | Wilda et al. (2004) |
| 2006 | DLBCL | Sanger | 1 | 1 (100.0) | PRDM1 | (pasqualucciInactivationPRDM1BLIMP12006a?) |
| 2006 | PMBL | Sanger | 2 | 1 (50.0) | GPR126 | (wenigerMutationsTumorSuppressor2006a?) |
| 2007 | DLBCL | Sanger | 1 | 1 (100.0) | FAS | Scholl et al. (2007) |
| 2008 | DLBCL | Sanger | 1 | 1 (100.0) | CARD11 | Lenz et al. (2008) |
| 2009 | DLBCL | Sanger | 1 | 1 (100.0) | NFKBIA | Lake et al. (2009) |
| 2009 | DLBCL | Sanger | 1 | 1 (100.0) | TNFAIP3 | (compagnoMutationsMultipleGenes2009a?) |
| 2009 | PMBL | Sanger | 1 | 1 (100.0) | STAT6 | (ritzRecurrentMutationsSTAT62009a?) |
| 2009 | PMBL | Sanger | 1 | 1 (100.0) | TNFAIP3 | (schmitzTNFAIP3A20Tumor2009a?) |
| 2010 | FL | Sanger | 1 | 1 (100.0) | TNFRSF14 | (cheungAcquiredTNFRSF14Mutations2010a?) |
| 2010 | DLBCL | RNA-seq/WGS | 1 | 1 (100.0) | EZH2 | (morinSomaticMutationsAltering2010a?) |
| 2011 | DLBCL | RNA-seq/WGS | 29 | 27 (93.1) | B2M | Morin et al. (2011) |
| 2011 | DLBCL | exome | 7 | 3 (42.9) | CD36 | Pasqualucci et al. (2011) |
| 2011 | DLBCL | Sanger | 1 | 1 (100.0) | MYD88 | (ngoOncogenicallyActiveMYD882011a?) |
| 2011 | FL | exome | 2 | 2 (100.0) | CREBBP | (pasqualucciInactivatingMutationsAcetyltransferase2011a?) |
| 2011 | DLBCL | exome/Sanger | 1 | 1 (100.0) | BRAF | (tiacciBRAFMutationsHairycell2011a?) |
| 2011 | MZL | Sanger | 5 | 4 (80.0) | BIRC3 | (rossiAlterationBIRC3Multiple2011a?) |
| 2012 | MZL | exome | 21 | 10 (47.6) | ARID1A | (rossiCodingGenomeSplenic2012c?) |
| 2012 | BL | RNA-seq/WGS/exome | 5 | 5 (100.0) | CCND3 | (richterRecurrentMutationID32012a?) |
| 2012 | DLBCL | Sanger | 1 | 0 (0.0) | MIR142 | (kwanhianMicroRNA142Mutated202012b?) |
| 2012 | DLBCL | WGS | 1 | 1 (100.0) | CXCR4 | Khodabakhshi et al. (2012) |
| 2012 | PMBL | Array/Sanger | 2 | 2 (100.0) | MAP3K14 | (ottoGeneticLesionsTRAF32012a?) |
| 2012 | DLBCL | exome | 39 | 18 (46.2) | ACTB | (lohrDiscoveryPrioritizationSomatic2012a?) |
| 2012 | MZL | Panel | 2 | 2 (100.0) | CARD11 | (yanBCRTLRSignaling2012a?) |
| 2012 | BL | exome | 60 | 3 (5.0) | ACAD9 | Love et al. (2012) |
| 2012 | BL | RNA-seq | 20 | 4 (20.0) | C16orf48 | Schmitz et al. (2012) |
| 2012 | MZL | Array/Sanger | 1 | 1 (100.0) | ATM | Braggio et al. (2012) |
| 2013 | MCL | WGS/exome | 27 | 11 (40.7) | ABCA3 | Beà et al. (2013) |
| 2013 | DLBCL | exome | 16 | 8 (50.0) | ARID1A | Zhang et al. (2013) |
| 2013 | DLBCL | Sanger | 1 | 1 (100.0) | EBF1 | Bohle et al. (2013) |
| 2013 | DLBCL | WGS | 38 | 9 (23.7) | ABI3BP | Morin et al. (2013) |
| 2013 | MZL | exome | 8 | 0 (0.0) | AMOTL1 | Parry et al. (2013) |
| 2014 | MCL | exome | 28 | 2 (7.1) | ANK2 | Zhang et al. (2014) |
| 2014 | PMBL | WGS/Sanger | 1 | 1 (100.0) | PTPN1 | (gunawardanaRecurrentSomaticMutations2014c?) |
| 2014 | BL | Sanger | 3 | 1 (33.3) | ARHGEF1 | (muppidiLossSignalingGa132014b?) |
| 2015 | BL | RNA-seq | 1 | 0 (0.0) | CCNF | (abateDistinctViralMutational2015a?) |
| 2015 | DLBCL | Sanger | 1 | 1 (100.0) | STAT6 | (yildizActivatingSTAT6Mutations2015c?) |
| 2015 | PMBL | Sanger | 1 | 1 (100.0) | CIITA | (mottokGenomicAlterationsCIITA2015b?) |
| 2015 | PMBL | Sanger | 1 | 1 (100.0) | CD58 | (schneiderAlterationsCD58Gene2015a?) |
| 2015 | PMBL | exome | 29 | 11 (37.9) | ARIH2 | (reichelFlowSortingExome2015a?) |
| 2015 | DLBCL | Sanger | 1 | 0 (0.0) | MAP2K1 | Shin et al. (2015) |
| 2016 | MZL | exome | 1 | 1 (100.0) | KLHL6 | Ganapathi et al. (2016) |
| 2016 | DLBCL | exome | 1 | 1 (100.0) | XPO1 | Mareschal et al. (2016) |
| 2016 | FL | WGS | 3 | 3 (100.0) | ATP6AP1 | (okosunRecurrentMTORC1activatingRRAGC2016a?) |
| 2016 | PMBL | Sanger | 1 | 1 (100.0) | XPO1 | (jardinRecurrentMutationsExportin2016a?) |
| 2016 | PMBL | exome/Sanger | 1 | 1 (100.0) | NFKBIE | Mansouri et al. (2016) |
| 2016 | FL | exome | 1 | 1 (100.0) | MAP2K1 | (louissaintPediatrictypeNodalFollicular2016a?) |
| 2016 | MZL | exome/panel | 31 | 8 (25.8) | ABCA13 | (spinaGeneticsNodalMarginal2016b?) |
| 2016 | MCL | exome | 1 | 1 (100.0) | CARD11 | Wu et al. (2016) |
| 2016 | DLBCL | exome | 2 | 2 (100.0) | NFKBIE | Morin et al. (2016) |
| 2017 | MZL | panel | 2 | 0 (0.0) | CD9B | van den Brand et al. (2017) |
| 2017 | MZL | exome | 28 | 2 (7.1) | ARHGAP20 | Jallades et al. (2017) |
| 2017 | FL | exome | 22 | 17 (77.3) | ARID1A | (krysiakRecurrentSomaticMutations2017b?) |
| 2017 | DLBCL | exome | 3 | 3 (100.0) | BTK | (albuquerqueEnhancingKnowledgeDiscovery2017a?) |
| 2017 | DLBCL | exome | 59 | 6 (10.2) | ANKRD17 | Reddy et al. (2017) |
| 2018 | PMBL | exome | 10 | 1 (10.0) | AKAP6 | (tiacciPervasiveMutationsJAKSTAT2018b?) |
| 2018 | DLBCL | exome | 19 | 2 (10.5) | CCL4 | (chapuyMolecularSubtypesDiffuse2018b?) |
| 2018 | PMBL | Sanger | 1 | 1 (100.0) | IL4R | (viganoSomaticIL4RMutations2018b?) |
| 2018 | DLBCL | WGS | 19 | 7 (36.8) | AICDA | Arthur et al. (2018) |
| 2018 | DLBCL | exome | 16 | 7 (43.8) | CXCR5 | (schmitzGeneticsPathogenesisDiffuse2018a?) |
| 2019 | PMBL | exome | 7 | 4 (57.1) | ACTB | (wienandGenomicAnalysesFlowsorted2019b?) |
| 2019 | BL | exome | 1 | 0 (0.0) | KMT2C | Zhou et al. (2019) |
| 2019 | BL | RNA-seq/exome | 39 | 4 (10.3) | ALPK2 | Panea et al. (2019) |
| 2019 | BL | WGS | 13 | 9 (69.2) | BACH2 | Grande et al. (2019) |
| 2019 | PMBL | exome | 21 | 6 (28.6) | CISH | (mottokIntegrativeGenomicAnalysis2019b?) |
| 2020 | MCL | WGS | 5 | 3 (60.0) | BCOR | (nadeuGenomicEpigenomicInsights2020b?) |
| 2020 | FL | panel | 1 | 1 (100.0) | CTSS | (barariaCathepsinAlterationsInduce2020c?) |
| 2020 | DLBCL | exome/panel | 1 | 1 (100.0) | MS4A1 | Rushton et al. (2020) |
| 2020 | MCL | WGS/exome | 7 | 6 (85.7) | B2M | Pararajalingam et al. (2020) |
| 2020 | PMBL | panel | 10 | 1 (10.0) | ACTG1 | Desch et al. (2020) |
| 2021 | DLBCL | WGS | 38 | 3 (7.9) | ACTG1 | (hubschmannMutationalMechanismsShaping2021b?) |
| 2021 | PMBL | exome | 11 | 5 (45.5) | ABCA13 | (sarkozyMutationalLandscapeGray2021a?) |
| 2021 | PMBL | exome | 14 | 6 (42.9) | BIRC3 | (dunsCharacterizationDLBCLPMBL2021b?) |
| 2022 | BL | panel | 25 | 0 (0.0) | ADAMTS5 | (burkhardtClinicalRelevanceMolecular2022b?) |
| 2023 | BL | WGS | 6 | 2 (33.3) | CDKN2C | Thomas et al. (2023) |
| 2023 | FL | exome | 20 | 1 (5.0) | ABL2 | (russler-germainMutationsAssociatedProgression2023b?) |
| 2023 | PMBL | exome | 7 | 2 (28.6) | ARID5B | Gomez et al. (2023) |
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