Year Study
1992 Tanaka et al. (1992)
1992 Johnston and Carroll (1992)
2001 (pasqualucciHypermutationMultipleProtooncogenes2001a?)
2004 Wilda et al. (2004)
2006 (wenigerMutationsTumorSuppressor2006a?)
2006 (pasqualucciInactivationPRDM1BLIMP12006a?)
2007 Scholl et al. (2007)
2008 Lenz et al. (2008)
2008 Trøen et al. (2008)
2009 (ritzRecurrentMutationsSTAT62009a?)
2009 (schmitzTNFAIP3A20Tumor2009a?)
2009 (compagnoMutationsMultipleGenes2009a?)
2009 Lake et al. (2009)
2010 (cheungAcquiredTNFRSF14Mutations2010a?)
2010 (morinSomaticMutationsAltering2010a?)
2011 Pasqualucci et al. (2011)
2011 (pasqualucciInactivatingMutationsAcetyltransferase2011a?)
2011 (ngoOncogenicallyActiveMYD882011a?)
2011 (tiacciBRAFMutationsHairycell2011a?)
2011 Morin et al. (2011)
2011 (rossiAlterationBIRC3Multiple2011a?)
2012 (ottoGeneticLesionsTRAF32012a?)
2012 (richterRecurrentMutationID32012a?)
2012 (rossiCodingGenomeSplenic2012c?)
2012 (yanBCRTLRSignaling2012a?)
2012 (kwanhianMicroRNA142Mutated202012b?)
2012 Khodabakhshi et al. (2012)
2012 Love et al. (2012)
2012 Schmitz et al. (2012)
2012 (lohrDiscoveryPrioritizationSomatic2012a?)
2012 Braggio et al. (2012)
2013 Morin et al. (2013)
2013 Bohle et al. (2013)
2013 Beà et al. (2013)
2013 Zhang et al. (2013)
2013 Parry et al. (2013)
2014 Zhang et al. (2014)
2014 (muppidiLossSignalingGa132014b?)
2014 Ohgami et al. (2014)
2014 (gunawardanaRecurrentSomaticMutations2014c?)
2015 (schneiderAlterationsCD58Gene2015a?)
2015 (reichelFlowSortingExome2015a?)
2015 (yildizActivatingSTAT6Mutations2015c?)
2015 Shin et al. (2015)
2015 (mottokGenomicAlterationsCIITA2015b?)
2015 (abateDistinctViralMutational2015a?)
2016 (jardinRecurrentMutationsExportin2016a?)
2016 Wu et al. (2016)
2016 (okosunRecurrentMTORC1activatingRRAGC2016a?)
2016 Morin et al. (2016)
2016 Mareschal et al. (2016)
2016 (spinaGeneticsNodalMarginal2016b?)
2016 Ganapathi et al. (2016)
2016 (louissaintPediatrictypeNodalFollicular2016a?)
2016 Mansouri et al. (2016)
2017 (krysiakRecurrentSomaticMutations2017b?)
2017 Reddy et al. (2017)
2017 Oricchio et al. (2017)
2017 Jallades et al. (2017)
2017 van den Brand et al. (2017)
2017 (albuquerqueEnhancingKnowledgeDiscovery2017a?)
2018 (viganoSomaticIL4RMutations2018b?)
2018 (tiacciPervasiveMutationsJAKSTAT2018b?)
2018 Arthur et al. (2018)
2018 (chapuyMolecularSubtypesDiffuse2018b?)
2018 (schmitzGeneticsPathogenesisDiffuse2018a?)
2019 Zhou et al. (2019)
2019 Grande et al. (2019)
2019 Panea et al. (2019)
2019 (wienandGenomicAnalysesFlowsorted2019b?)
2019 (mottokIntegrativeGenomicAnalysis2019b?)
2020 Pararajalingam et al. (2020)
2020 Desch et al. (2020)
2020 (nadeuGenomicEpigenomicInsights2020b?)
2020 (barariaCathepsinAlterationsInduce2020c?)
2020 Rushton et al. (2020)
2021 (sarkozyMutationalLandscapeGray2021a?)
2021 (hubschmannMutationalMechanismsShaping2021b?)
2021 (dunsCharacterizationDLBCLPMBL2021b?)
2022 (burkhardtClinicalRelevanceMolecular2022b?)
2023 Gomez et al. (2023)
2023 Thomas et al. (2023)
2023 (russler-germainMutationsAssociatedProgression2023b?)

References

Arthur, Sarah E., Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K. Rushton, Anja Mottok, et al. 2018. “Genome-Wide Discovery of Somatic Regulatory Variants in Diffuse Large B-cell Lymphoma.” Nature Communications 9 (1): 4001. https://doi.org/10.1038/s41467-018-06354-3.
Beà, Sílvia, Rafael Valdés-Mas, Alba Navarro, Itziar Salaverria, David Martín-Garcia, Pedro Jares, Eva Giné, et al. 2013. “Landscape of Somatic Mutations and Clonal Evolution in Mantle Cell Lymphoma.” Proceedings of the National Academy of Sciences 110 (45): 18250–55. https://doi.org/10.1073/pnas.1314608110.
Bohle, V., C. Döring, M.-L. Hansmann, and R. Küppers. 2013. “Role of Early B-cell Factor 1 (Ebf1) in Hodgkin Lymphoma.” Leukemia 27 (3): 671–79. https://doi.org/10.1038/leu.2012.280.
Braggio, Esteban, Ahmet Dogan, Jonathan J. Keats, Wee J. Chng, Gaofeng Huang, Julie M. Matthews, Matthew J. Maurer, et al. 2012. “Genomic Analysis of Marginal Zone and Lymphoplasmacytic Lymphomas Identified Common and Disease-Specific Abnormalities.” Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc 25 (5): 651–60. https://doi.org/10.1038/modpathol.2011.213.
Brand, Michiel van den, Jos Rijntjes, Konnie M. Hebeda, Laura Menting, Carolyn V. Bregitha, Wendy B. C. Stevens, Walter J. F. M. van der Velden, Bastiaan B. J. Tops, J. Han J. M. van Krieken, and Patricia J. T. A. Groenen. 2017. “Recurrent Mutations in Genes Involved in Nuclear Factor-κB Signalling in Nodal Marginal Zone Lymphoma-Diagnostic and Therapeutic Implications.” Histopathology 70 (2): 174–84. https://doi.org/10.1111/his.13015.
Desch, Ann-Kathrin, Kristin Hartung, Ante Botzen, Alexander Brobeil, Mathias Rummel, Lars Kurch, Thomas Georgi, et al. 2020. “Genotyping Circulating Tumor DNA of Pediatric Hodgkin Lymphoma.” Leukemia 34 (1): 151–66. https://doi.org/10.1038/s41375-019-0541-6.
Ganapathi, Karthik A., Vaidehi Jobanputra, Fabio Iwamoto, Preti Jain, Jinli Chen, Luciano Cascione, Odelia Nahum, et al. 2016. “The Genetic Landscape of Dural Marginal Zone Lymphomas.” Oncotarget 7 (28): 43052–61. https://doi.org/10.18632/oncotarget.9678.
Gomez, Felicia, Bryan Fisk, Joshua F. McMichael, Matthew Mosior, Jennifer A. Foltz, Zachary L. Skidmore, Eric J. Duncavage, et al. 2023. “Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma.” Cancer Research Communications 3 (11): 2312–30. https://doi.org/10.1158/2767-9764.CRC-23-0140.
Grande, Bruno M., Daniela S. Gerhard, Aixiang Jiang, Nicholas B. Griner, Jeremy S. Abramson, Thomas B. Alexander, Hilary Allen, et al. 2019. “Genome-Wide Discovery of Somatic Coding and Noncoding Mutations in Pediatric Endemic and Sporadic Burkitt Lymphoma.” Blood 133 (12): 1313–24. https://doi.org/10.1182/blood-2018-09-871418.
Jallades, Laurent, Lucile Baseggio, Pierre Sujobert, Sarah Huet, Kaddour Chabane, Evelyne Callet-Bauchu, Aurélie Verney, et al. 2017. “Exome Sequencing Identifies Recurrent BCOR Alterations and the Absence of Klf2, Tnfaip3 and Myd88 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma.” Haematologica 102 (10): 1758–66. https://doi.org/10.3324/haematol.2016.160192.
Johnston, J. M., and W. L. Carroll. 1992. “C-Myc Hypermutation in Burkitt’s Lymphoma.” Leukemia & Lymphoma 8 (6): 431–39. https://doi.org/10.3109/10428199209051025.
Khodabakhshi, Alireza Hadj, Ryan D. Morin, Anthony P. Fejes, Andrew J. Mungall, Karen L. Mungall, Madison Bolger-Munro, Nathalie A. Johnson, et al. 2012. “Recurrent Targets of Aberrant Somatic Hypermutation in Lymphoma.” Oncotarget 3 (11): 1308–19.
Lake, Annette, Lesley A. Shield, Pablo Cordano, Daniel T. Y. Chui, Julie Osborne, Shauna Crae, Katherine S. Wilson, et al. 2009. “Mutations of NFKBIA, Encoding IkappaB Alpha, Are a Recurrent Finding in Classical Hodgkin Lymphoma but Are Not a Unifying Feature of Non-EBV-associated Cases.” International Journal of Cancer 125 (6): 1334–42. https://doi.org/10.1002/ijc.24502.
Lenz, Georg, R Eric Davis, Vu N Ngo, Lloyd Lam, Thaddeus C George, George W Wright, Sandeep S Dave, et al. 2008. “Oncogenic Card11 Mutations in Human Diffuse Large B Cell Lymphoma.” Science 319 (5870): 1676–79. https://doi.org/10.1126/science.1153629.
Love, Cassandra, Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Rodney Miles, Kristy L. Richards, et al. 2012. “The Genetic Landscape of Mutations in Burkitt Lymphoma.” Nature Genetics 44 (12): 1321–25. https://doi.org/10.1038/ng.2468.
Mansouri, Larry, Daniel Noerenberg, Emma Young, Elena Mylonas, Maysaa Abdulla, Mareike Frick, Fazila Asmar, et al. 2016. “Frequent NFKBIE Deletions Are Associated with Poor Outcome in Primary Mediastinal B-cell Lymphoma.” Blood 128 (23): 2666–70. https://doi.org/10.1182/blood-2016-03-704528.
Mareschal, Sylvain, Sydney Dubois, Pierre-Julien Viailly, Philippe Bertrand, Elodie Bohers, Catherine Maingonnat, Jean-Philippe Jaïs, et al. 2016. “Whole Exome Sequencing of Relapsed/Refractory Patients Expands the Repertoire of Somatic Mutations in Diffuse Large B-cell Lymphoma.” Genes, Chromosomes & Cancer 55 (3): 251–67. https://doi.org/10.1002/gcc.22328.
Morin, Ryan D., Sarit Assouline, Miguel Alcaide, Arezoo Mohajeri, Rebecca L. Johnston, Lauren Chong, Jasleen Grewal, et al. 2016. “Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 22 (9): 2290–300. https://doi.org/10.1158/1078-0432.CCR-15-2123.
Morin, Ryan D., Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya, Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, et al. 2011. “Frequent Mutation of Histone-Modifying Genes in Non-Hodgkin Lymphoma.” Nature 476 (7360): 298–303. https://doi.org/10.1038/nature10351.
Morin, Ryan D., Karen Mungall, Erin Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, et al. 2013. “Mutational and Structural Analysis of Diffuse Large B-cell Lymphoma Using Whole-Genome Sequencing.” Blood 122 (7): 1256–65. https://doi.org/10.1182/blood-2013-02-483727.
Ohgami, Robert S., Lisa Ma, Ahmad Monabati, James L. Zehnder, and Daniel A. Arber. 2014. “Stat3 Mutations Are Present in Aggressive B-cell Lymphomas Including a Subset of Diffuse Large B-cell Lymphomas with Cd30 Expression.” Haematologica 99 (7): e105–107. https://doi.org/10.3324/haematol.2013.101543.
Oricchio, Elisa, Natalya Katanayeva, Maria Christine Donaldson, Stephanie Sungalee, Joyce P. Pasion, Wendy Béguelin, Elena Battistello, et al. 2017. “Genetic and Epigenetic Inactivation of Sestrin1 Controls mTORC1 and Response to Ezh2 Inhibition in Follicular Lymphoma.” Science Translational Medicine 9 (396): eaak9969. https://doi.org/10.1126/scitranslmed.aak9969.
Panea, R., C. Love, Jennifer R. Shingleton, Anupama Reddy, J. Bailey, A. Moormann, J. Otieno, et al. 2019. “The Whole Genome Landscape of Burkitt Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2019001880.
Pararajalingam, Prasath, Krysta M. Coyle, Sarah E. Arthur, Nicole Thomas, Miguel Alcaide, Barbara Meissner, Merrill Boyle, et al. 2020. “Coding and Noncoding Drivers of Mantle Cell Lymphoma Identified Through Exome and Genome Sequencing.” Blood 136 (5): 572–84. https://doi.org/10.1182/blood.2019002385.
Parry, Marina, Matthew J. J. Rose-Zerilli, Jane Gibson, Sarah Ennis, Renata Walewska, Jade Forster, Helen Parker, et al. 2013. “Whole Exome Sequencing Identifies Novel Recurrently Mutated Genes in Patients with Splenic Marginal Zone Lymphoma.” PloS One 8 (12): e83244. https://doi.org/10.1371/journal.pone.0083244.
Pasqualucci, Laura, Vladimir Trifonov, Giulia Fabbri, Jing Ma, Davide Rossi, Annalisa Chiarenza, Victoria A. Wells, et al. 2011. “Analysis of the Coding Genome of Diffuse Large B-cell Lymphoma.” Nature Genetics 43 (9): 830–37. https://doi.org/10.1038/ng.892.
Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. “Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.” Cell 171 (2): 481–494.e15.
Rushton, Christopher K., Sarah E. Arthur, Miguel Alcaide, Matthew Cheung, Aixiang Jiang, Krysta M. Coyle, Kirstie L. S. Cleary, et al. 2020. “Genetic and Evolutionary Patterns of Treatment Resistance in Relapsed B-cell Lymphoma.” Blood Advances 4 (13): 2886–98. https://doi.org/10.1182/bloodadvances.2020001696.
Schmitz, Roland, Ryan M. Young, Michele Ceribelli, Sameer Jhavar, Wenming Xiao, Meili Zhang, George Wright, et al. 2012. “Burkitt Lymphoma Pathogenesis and Therapeutic Targets from Structural and Functional Genomics.” Nature 490 (7418): 116–20. https://doi.org/10.1038/nature11378.
Scholl, Vanesa, Claudio Gustavo Stefanoff, Rocio Hassan, Nelson Spector, and Ilana Zalcberg Renault. 2007. “Mutations Within the 5’ Region of FAS/Cd95 Gene in Nodal Diffuse Large B-cell Lymphoma.” Leukemia & Lymphoma 48 (5): 957–63. https://doi.org/10.1080/10428190701230858.
Shin, Sang-Yong, Seung-Tae Lee, Hee-Jin Kim, Chang-Seok Ki, Chul Won Jung, Jong-Won Kim, and Sun-Hee Kim. 2015. “BRAF V600e and Map2k1 Mutations in Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma Cases.” Annals of Laboratory Medicine 35 (2): 257–59. https://doi.org/10.3343/alm.2015.35.2.257.
Tanaka, S., D. C. Louie, J. A. Kant, and J. C. Reed. 1992. “Frequent Incidence of Somatic Mutations in Translocated Bcl2 Oncogenes of Non-Hodgkin’s Lymphomas.” Blood 79 (1): 229–37. https://doi.org/10.1182/blood.V79.1.229.229.
Thomas, Nicole, Kostiantyn Dreval, Daniela S. Gerhard, Laura K. Hilton, Jeremy S. Abramson, Richard F. Ambinder, Stefan Barta, et al. 2023. “Genetic Subgroups Inform on Pathobiology in Adult and Pediatric Burkitt Lymphoma.” Blood 141 (8): 904–16. https://doi.org/10.1182/blood.2022016534.
Trøen, Gunhild, Iwona Wlodarska, Abdirashid Warsame, Silvia Hernández Llodrà, Christiane De Wolf-Peeters, and Jan Delabie. 2008. “Notch2 Mutations in Marginal Zone Lymphoma.” Haematologica 93 (7): 1107–9. https://doi.org/10.3324/haematol.11635.
Wilda, M., J. Bruch, L. Harder, D. Rawer, A. Reiter, A. Borkhardt, and W. Woessmann. 2004. “Inactivation of the ARF-MDM-2-p53 Pathway in Sporadic Burkitt’s Lymphoma in Children.” Leukemia 18 (3): 584–88. https://doi.org/10.1038/sj.leu.2403254.
Wu, Chenglin, Noel Fcc de Miranda, Longyun Chen, Agata M. Wasik, Larry Mansouri, Wojciech Jurczak, Krystyna Galazka, et al. 2016. “Genetic Heterogeneity in Primary and Relapsed Mantle Cell Lymphomas: Impact of Recurrent Card11 Mutations.” Oncotarget 7 (25): 38180–90. https://doi.org/10.18632/oncotarget.9500.
Zhang, Jenny, Vladimir Grubor, Cassandra L Love, Anjishnu Banerjee, Kristy L Richards, Piotr A Mieczkowski, Cherie Dunphy, et al. 2013. “Genetic Heterogeneity of Diffuse Large B-cell Lymphoma.” Proceedings of the National Academy of Sciences of the United States of America 110: 1398–1403. https://doi.org/10.1073/pnas.1205299110.
Zhang, Jenny, Dereje Jima, Andrea B. Moffitt, Qingquan Liu, Magdalena Czader, Eric D. Hsi, Yuri Fedoriw, et al. 2014. “The Genomic Landscape of Mantle Cell Lymphoma Is Related to the Epigenetically Determined Chromatin State of Normal B Cells.” Blood 123 (19): 2988–96. https://doi.org/10.1182/blood-2013-07-517177.
Zhou, Peixun, Alex E. Blain, Alexander M. Newman, Masood Zaka, George Chagaluka, Filbert R. Adlar, Ugonna T. Offor, et al. 2019. “Sporadic and Endemic Burkitt Lymphoma Have Frequent Foxo1 Mutations but Distinct Hotspots in the AKT Recognition Motif.” Blood Advances 3 (14): 2118–27. https://doi.org/10.1182/bloodadvances.2018029546.

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

Disclaimer

The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

Share — copy and redistribute the material in any medium or format for any purpose, even commercially.

Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.