Entity Method Paired samples Unpaired samples Cell lines Example gene Study
DLBCL Sanger 0 5 0 BCL2 Tanaka et al. (1992)
BL Sanger 0 0 9 MYC Johnston and Carroll (1992)
DLBCL Sanger 11 28 0 MYC L. Pasqualucci et al. (2001)
BL Sanger 0 24 0 TP53 Wilda et al. (2004)
DLBCL Sanger 134 0 20 PRDM1 Laura Pasqualucci et al. (2006)
PMBL Sanger GPR126 Weniger et al. (2006)
DLBCL Sanger FAS Scholl et al. (2007)
DLBCL Sanger 6 217 21 CARD11 Lenz et al. (2008)
DLBCL Sanger NFKBIA Lake et al. (2009)
DLBCL Sanger 0 101 TNFAIP3 Compagno et al. (2009)
PMBL Sanger STAT6 Ritz et al. (2009)
PMBL Sanger TNFAIP3 Schmitz et al. (2009)
FL Sanger 11 251 0 TNFRSF14 Cheung et al. (2010)
DLBCL/FL RNA-seq/WGS 1 31 7 EZH2 Morin et al. (2010)
DLBCL Sanger 0 382 20 MYD88 Ngo et al. (2011)
DLBCL RNA-seq/WGS 14 103 10 B2M Morin et al. (2011)
DLBCL exome 6 92 23 CD36 Laura Pasqualucci, Trifonov, et al. (2011)
DLBCL/FL exome 7 134 0 CREBBP Laura Pasqualucci, Dominguez-Sola, et al. (2011)
DLBCL exome/Sanger 1 1 (100.0) BRAF Tiacci et al. (2011)
MZL Sanger 5 4 (80.0) BIRC3 Rossi et al. (2011)
MZL exome 21 10 (47.6) ARID1A Rossi et al. (2012)
BL RNA-seq/WGS/exome 5 5 (100.0) CCND3 Richter et al. (2012)
DLBCL Sanger 1 0 (0.0) MIR142 Kwanhian et al. (2012)
DLBCL WGS 1 1 (100.0) CXCR4 Khodabakhshi et al. (2012)
PMBL Array/Sanger 2 2 (100.0) MAP3K14 Otto et al. (2012)
DLBCL exome 39 18 (46.2) ACTB Lohr et al. (2012)
MZL Panel 2 2 (100.0) CARD11 Yan et al. (2012)
BL exome 60 3 (5.0) ACAD9 Love et al. (2012)
BL RNA-seq 20 4 (20.0) C16orf48 Schmitz et al. (2012)
MZL Array/Sanger 1 1 (100.0) ATM Braggio et al. (2012)
MCL WGS/exome 27 11 (40.7) ABCA3 Beà et al. (2013)
DLBCL exome 16 8 (50.0) ARID1A Zhang et al. (2013)
DLBCL Sanger 1 1 (100.0) EBF1 Bohle et al. (2013)
DLBCL WGS 38 9 (23.7) ABI3BP Morin et al. (2013)
MZL exome 8 0 (0.0) AMOTL1 Parry et al. (2013)
MCL exome 28 2 (7.1) ANK2 Zhang et al. (2014)
PMBL WGS/Sanger 1 1 (100.0) PTPN1 Gunawardana et al. (2014)
BL Sanger 3 1 (33.3) ARHGEF1 Muppidi et al. (2014)
BL RNA-seq 1 0 (0.0) CCNF Abate et al. (2015)
DLBCL Sanger 1 1 (100.0) STAT6 Yildiz et al. (2015)
PMBL Sanger 1 1 (100.0) CIITA Mottok et al. (2015)
PMBL Sanger 1 1 (100.0) CD58 Schneider et al. (2015)
PMBL exome 29 11 (37.9) ARIH2 Reichel et al. (2015)
DLBCL Sanger 1 0 (0.0) MAP2K1 Shin et al. (2015)
MZL exome 1 1 (100.0) KLHL6 Ganapathi et al. (2016)
DLBCL exome 1 1 (100.0) XPO1 Mareschal et al. (2016)
FL WGS 3 3 (100.0) ATP6AP1 Okosun et al. (2016)
PMBL Sanger 1 1 (100.0) XPO1 Jardin et al. (2016)
PMBL exome/Sanger 1 1 (100.0) NFKBIE Mansouri et al. (2016)
FL exome 1 1 (100.0) MAP2K1 Louissaint et al. (2016)
MZL exome/panel 31 8 (25.8) ABCA13 Spina et al. (2016)
MCL exome 1 1 (100.0) CARD11 Wu et al. (2016)
DLBCL exome 2 2 (100.0) NFKBIE Morin et al. (2016)
MZL panel 2 0 (0.0) CD9B van den Brand et al. (2017)
MZL exome 28 2 (7.1) ARHGAP20 Jallades et al. (2017)
FL exome 22 17 (77.3) ARID1A Krysiak et al. (2017)
DLBCL exome 3 3 (100.0) BTK Albuquerque et al. (2017)
DLBCL exome 59 6 (10.2) ANKRD17 Reddy et al. (2017)
PMBL exome 10 1 (10.0) AKAP6 Tiacci et al. (2018)
DLBCL exome 19 2 (10.5) CCL4 Chapuy et al. (2018)
PMBL Sanger 1 1 (100.0) IL4R Viganò et al. (2018)
DLBCL WGS 19 7 (36.8) AICDA Arthur et al. (2018)
DLBCL exome 16 7 (43.8) CXCR5 Schmitz et al. (2018)
PMBL exome 7 4 (57.1) ACTB Wienand et al. (2019)
BL exome 1 0 (0.0) KMT2C Zhou et al. (2019)
BL RNA-seq/exome 39 4 (10.3) ALPK2 Panea et al. (2019)
BL WGS 13 9 (69.2) BACH2 Grande et al. (2019)
PMBL exome 21 6 (28.6) CISH Mottok et al. (2019)
MCL WGS 5 3 (60.0) BCOR Nadeu et al. (2020)
FL panel 1 1 (100.0) CTSS Bararia et al. (2020)
DLBCL exome/panel 1 1 (100.0) MS4A1 Rushton et al. (2020)
MCL WGS/exome 7 6 (85.7) B2M Pararajalingam et al. (2020)
PMBL panel 10 1 (10.0) ACTG1 Desch et al. (2020)
DLBCL WGS 38 3 (7.9) ACTG1 Hübschmann et al. (2021)
PMBL exome 11 5 (45.5) ABCA13 Sarkozy et al. (2021)
PMBL exome 14 6 (42.9) BIRC3 Duns et al. (2021)
BL panel 25 0 (0.0) ADAMTS5 Burkhardt et al. (2022)
BL WGS 6 2 (33.3) CDKN2C Thomas et al. (2023)
FL exome 20 1 (5.0) ABL2 Russler-Germain et al. (2023)
PMBL exome 7 2 (28.6) ARID5B Gomez et al. (2023)

References

Abate, F., M. Ambrosio, L. Mundo, M. Laginestra, F. Fuligni, M. Rossi, Sakellarios Zairis, et al. 2015. “Distinct Viral and Mutational Spectrum of Endemic Burkitt Lymphoma.” PLoS Pathogens 11. https://doi.org/10.1371/journal.ppat.1005158.
Albuquerque, Marco A., Bruno M. Grande, Elie J. Ritch, Prasath Pararajalingam, Selin Jessa, Martin Krzywinski, Jasleen K. Grewal, Sohrab P. Shah, Paul C. Boutros, and Ryan D. Morin. 2017. “Enhancing Knowledge Discovery from Cancer Genomics Data with Galaxy.” GigaScience 6 (5): 1–13. https://doi.org/10.1093/gigascience/gix015.
Arthur, Sarah E., Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K. Rushton, Anja Mottok, et al. 2018. “Genome-Wide Discovery of Somatic Regulatory Variants in Diffuse Large B-cell Lymphoma.” Nature Communications 9 (1): 4001. https://doi.org/10.1038/s41467-018-06354-3.
Bararia, Deepak, Johannes A. Hildebrand, Sebastian Stolz, Sarah Haebe, Stefan Alig, Christopher P. Trevisani, Francisco Osorio-Barrios, et al. 2020. “Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma.” Cell Reports 31 (5): 107522. https://doi.org/10.1016/j.celrep.2020.107522.
Beà, Sílvia, Rafael Valdés-Mas, Alba Navarro, Itziar Salaverria, David Martín-Garcia, Pedro Jares, Eva Giné, et al. 2013. “Landscape of Somatic Mutations and Clonal Evolution in Mantle Cell Lymphoma.” Proceedings of the National Academy of Sciences 110 (45): 18250–55. https://doi.org/10.1073/pnas.1314608110.
Bohle, V., C. Döring, M.-L. Hansmann, and R. Küppers. 2013. “Role of Early B-cell Factor 1 (Ebf1) in Hodgkin Lymphoma.” Leukemia 27 (3): 671–79. https://doi.org/10.1038/leu.2012.280.
Braggio, Esteban, Ahmet Dogan, Jonathan J. Keats, Wee J. Chng, Gaofeng Huang, Julie M. Matthews, Matthew J. Maurer, et al. 2012. “Genomic Analysis of Marginal Zone and Lymphoplasmacytic Lymphomas Identified Common and Disease-Specific Abnormalities.” Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc 25 (5): 651–60. https://doi.org/10.1038/modpathol.2011.213.
Brand, Michiel van den, Jos Rijntjes, Konnie M. Hebeda, Laura Menting, Carolyn V. Bregitha, Wendy B. C. Stevens, Walter J. F. M. van der Velden, Bastiaan B. J. Tops, J. Han J. M. van Krieken, and Patricia J. T. A. Groenen. 2017. “Recurrent Mutations in Genes Involved in Nuclear Factor-κB Signalling in Nodal Marginal Zone Lymphoma-Diagnostic and Therapeutic Implications.” Histopathology 70 (2): 174–84. https://doi.org/10.1111/his.13015.
Burkhardt, Birgit, Ulf Michgehl, Jonas Rohde, Tabea Erdmann, Philipp Berning, Katrin Reutter, Marius Rohde, et al. 2022. “Clinical Relevance of Molecular Characteristics in Burkitt Lymphoma Differs According to Age.” Nature Communications 13 (1): 3881. https://doi.org/10.1038/s41467-022-31355-8.
Chapuy, Bjoern, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov, Robert A. Redd, Mike S. Lawrence, et al. 2018. “Molecular Subtypes of Diffuse Large B Cell Lymphoma Are Associated with Distinct Pathogenic Mechanisms and Outcomes.” Nature Medicine 24 (5): 679–90. https://doi.org/10.1038/s41591-018-0016-8.
Cheung, K.-John J., Nathalie A. Johnson, Joslynn G. Affleck, Tesa Severson, Christian Steidl, Susana Ben-Neriah, Jacqueline Schein, et al. 2010. “Acquired Tnfrsf14 Mutations in Follicular Lymphoma Are Associated with Worse Prognosis.” Cancer Research 70 (22): 9166–74. https://doi.org/10.1158/0008-5472.CAN-10-2460.
Compagno, Mara, Wei Keat Lim, Adina Grunn, Subhadra V. Nandula, Manisha Brahmachary, Qiong Shen, Francesco Bertoni, et al. 2009. “Mutations of Multiple Genes Cause Deregulation of NF-kappaB in Diffuse Large B-cell Lymphoma.” Nature 459 (7247): 717–21. https://doi.org/10.1038/nature07968.
Desch, Ann-Kathrin, Kristin Hartung, Ante Botzen, Alexander Brobeil, Mathias Rummel, Lars Kurch, Thomas Georgi, et al. 2020. “Genotyping Circulating Tumor DNA of Pediatric Hodgkin Lymphoma.” Leukemia 34 (1): 151–66. https://doi.org/10.1038/s41375-019-0541-6.
Duns, Gerben, Elena Viganò, Daisuke Ennishi, Clementine Sarkozy, Stacy S. Hung, Elizabeth Chavez, Katsuyoshi Takata, et al. 2021. “Characterization of DLBCL with a PMBL Gene Expression Signature.” Blood 138 (2): 136–48. https://doi.org/10.1182/blood.2020007683.
Ganapathi, Karthik A., Vaidehi Jobanputra, Fabio Iwamoto, Preti Jain, Jinli Chen, Luciano Cascione, Odelia Nahum, et al. 2016. “The Genetic Landscape of Dural Marginal Zone Lymphomas.” Oncotarget 7 (28): 43052–61. https://doi.org/10.18632/oncotarget.9678.
Gomez, Felicia, Bryan Fisk, Joshua F. McMichael, Matthew Mosior, Jennifer A. Foltz, Zachary L. Skidmore, Eric J. Duncavage, et al. 2023. “Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma.” Cancer Research Communications 3 (11): 2312–30. https://doi.org/10.1158/2767-9764.CRC-23-0140.
Grande, Bruno M., Daniela S. Gerhard, Aixiang Jiang, Nicholas B. Griner, Jeremy S. Abramson, Thomas B. Alexander, Hilary Allen, et al. 2019. “Genome-Wide Discovery of Somatic Coding and Noncoding Mutations in Pediatric Endemic and Sporadic Burkitt Lymphoma.” Blood 133 (12): 1313–24. https://doi.org/10.1182/blood-2018-09-871418.
Gunawardana, Jay, Fong Chun Chan, Adèle Telenius, Bruce Woolcock, Robert Kridel, King L. Tan, Susana Ben-Neriah, et al. 2014. “Recurrent Somatic Mutations of Ptpn1 in Primary Mediastinal B Cell Lymphoma and Hodgkin Lymphoma.” Nature Genetics 46 (4): 329–35. https://doi.org/10.1038/ng.2900.
Hübschmann, Daniel, Kortine Kleinheinz, Rabea Wagener, Stephan H. Bernhart, Cristina López, Umut H. Toprak, Stephanie Sungalee, et al. 2021. “Mutational Mechanisms Shaping the Coding and Noncoding Genome of Germinal Center Derived B-cell Lymphomas.” Leukemia 35 (7): 2002–16. https://doi.org/10.1038/s41375-021-01251-z.
Jallades, Laurent, Lucile Baseggio, Pierre Sujobert, Sarah Huet, Kaddour Chabane, Evelyne Callet-Bauchu, Aurélie Verney, et al. 2017. “Exome Sequencing Identifies Recurrent BCOR Alterations and the Absence of Klf2, Tnfaip3 and Myd88 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma.” Haematologica 102 (10): 1758–66. https://doi.org/10.3324/haematol.2016.160192.
Jardin, Fabrice, Anais Pujals, Laura Pelletier, Elodie Bohers, Vincent Camus, Sylvain Mareschal, Sydney Dubois, et al. 2016. “Recurrent Mutations of the Exportin 1 Gene (Xpo1) and Their Impact on Selective Inhibitor of Nuclear Export Compounds Sensitivity in Primary Mediastinal B-cell Lymphoma.” American Journal of Hematology 91 (9): 923–30. https://doi.org/10.1002/ajh.24451.
Johnston, J. M., and W. L. Carroll. 1992. “C-Myc Hypermutation in Burkitt’s Lymphoma.” Leukemia & Lymphoma 8 (6): 431–39. https://doi.org/10.3109/10428199209051025.
Khodabakhshi, Alireza Hadj, Ryan D. Morin, Anthony P. Fejes, Andrew J. Mungall, Karen L. Mungall, Madison Bolger-Munro, Nathalie A. Johnson, et al. 2012. Recurrent Targets of Aberrant Somatic Hypermutation in Lymphoma.” Oncotarget 3 (11): 1308–19.
Krysiak, Kilannin, Felicia Gomez, Brian S. White, Matthew Matlock, Christopher A. Miller, Lee Trani, Catrina C. Fronick, et al. 2017. “Recurrent Somatic Mutations Affecting B-cell Receptor Signaling Pathway Genes in Follicular Lymphoma.” Blood 129 (4): 473–83. https://doi.org/10.1182/blood-2016-07-729954.
Kwanhian, Wiyada, Dido Lenze, Julia Alles, Natalie Motsch, Stephanie Barth, Celina Döll, Jochen Imig, et al. 2012. MicroRNA-142 Is Mutated in about 20% of Diffuse Large B-cell Lymphoma.” Cancer Medicine 1 (2): 141–55. https://doi.org/10.1002/cam4.29.
Lake, Annette, Lesley A. Shield, Pablo Cordano, Daniel T. Y. Chui, Julie Osborne, Shauna Crae, Katherine S. Wilson, et al. 2009. “Mutations of NFKBIA, Encoding IkappaB Alpha, Are a Recurrent Finding in Classical Hodgkin Lymphoma but Are Not a Unifying Feature of Non-EBV-associated Cases.” International Journal of Cancer 125 (6): 1334–42. https://doi.org/10.1002/ijc.24502.
Lenz, Georg, R Eric Davis, Vu N Ngo, Lloyd Lam, Thaddeus C George, George W Wright, Sandeep S Dave, et al. 2008. “Oncogenic Card11 Mutations in Human Diffuse Large B Cell Lymphoma.” Science 319 (5870): 1676–79. https://doi.org/10.1126/science.1153629.
Lohr, Jens G., Petar Stojanov, Michael S. Lawrence, Daniel Auclair, Bjoern Chapuy, Carrie Sougnez, Peter Cruz-Gordillo, et al. 2012. “Discovery and Prioritization of Somatic Mutations in Diffuse Large B-cell Lymphoma (DLBCL) by Whole-Exome Sequencing.” Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. https://doi.org/10.1073/pnas.1121343109.
Louissaint, Abner, Kristian T. Schafernak, Julia T. Geyer, Alexandra E. Kovach, Mahmoud Ghandi, Dita Gratzinger, Christine G. Roth, et al. 2016. “Pediatric-Type Nodal Follicular Lymphoma: A Biologically Distinct Lymphoma with Frequent MAPK Pathway Mutations.” Blood 128 (8): 1093–1100. https://doi.org/10.1182/blood-2015-12-682591.
Love, Cassandra, Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Rodney Miles, Kristy L. Richards, et al. 2012. “The Genetic Landscape of Mutations in Burkitt Lymphoma.” Nature Genetics 44 (12): 1321–25. https://doi.org/10.1038/ng.2468.
Mansouri, Larry, Daniel Noerenberg, Emma Young, Elena Mylonas, Maysaa Abdulla, Mareike Frick, Fazila Asmar, et al. 2016. “Frequent NFKBIE Deletions Are Associated with Poor Outcome in Primary Mediastinal B-cell Lymphoma.” Blood 128 (23): 2666–70. https://doi.org/10.1182/blood-2016-03-704528.
Mareschal, Sylvain, Sydney Dubois, Pierre-Julien Viailly, Philippe Bertrand, Elodie Bohers, Catherine Maingonnat, Jean-Philippe Jaïs, et al. 2016. “Whole Exome Sequencing of Relapsed/Refractory Patients Expands the Repertoire of Somatic Mutations in Diffuse Large B-cell Lymphoma.” Genes, Chromosomes & Cancer 55 (3): 251–67. https://doi.org/10.1002/gcc.22328.
Morin, Ryan D., Sarit Assouline, Miguel Alcaide, Arezoo Mohajeri, Rebecca L. Johnston, Lauren Chong, Jasleen Grewal, et al. 2016. “Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 22 (9): 2290–300. https://doi.org/10.1158/1078-0432.CCR-15-2123.
Morin, Ryan D., Nathalie A. Johnson, Tesa M. Severson, Andrew J. Mungall, Jianghong An, Rodrigo Goya, Jessica E. Paul, et al. 2010. “Somatic Mutations Altering Ezh2 (Tyr641) in Follicular and Diffuse Large B-cell Lymphomas of Germinal-Center Origin.” Nature Genetics 42 (2): 181–85. https://doi.org/10.1038/ng.518.
Morin, Ryan D., Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya, Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, et al. 2011. “Frequent Mutation of Histone-Modifying Genes in Non-Hodgkin Lymphoma.” Nature 476 (7360): 298–303. https://doi.org/10.1038/nature10351.
Morin, Ryan D., Karen Mungall, Erin Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, et al. 2013. “Mutational and Structural Analysis of Diffuse Large B-cell Lymphoma Using Whole-Genome Sequencing.” Blood 122 (7): 1256–65. https://doi.org/10.1182/blood-2013-02-483727.
Mottok, Anja, Stacy S. Hung, Elizabeth A. Chavez, Bruce Woolcock, Adèle Telenius, Lauren C. Chong, Barbara Meissner, et al. 2019. “Integrative Genomic Analysis Identifies Key Pathogenic Mechanisms in Primary Mediastinal Large B-cell Lymphoma.” Blood 134 (10): 802–13. https://doi.org/10.1182/blood.2019001126.
Mottok, Anja, Bruce Woolcock, Fong Chun Chan, King Mong Tong, Lauren Chong, Pedro Farinha, Adèle Telenius, et al. 2015. “Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression.” Cell Reports 13 (7): 1418–31. https://doi.org/10.1016/j.celrep.2015.10.008.
Muppidi, J., R. Schmitz, Jesse A. Green, Jesse A. Green, Wenming Xiao, Adrien B. Larsen, S. Braun, et al. 2014. “Loss of Signaling via Gα13 in Germinal Center B Cell-Derived Lymphoma.” Nature 516: 254–58. https://doi.org/10.1038/nature13765.
Nadeu, F., D. Martín-García, G. Clot, A. Díaz-Navarro, M. Duran-Ferrer, A. Navarro, Roser Vilarrasa-Blasi, et al. 2020. “Genomic and Epigenomic Insights into the Origin, Pathogenesis and Clinical Behavior of Mantle Cell Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2020005289.
Ngo, Vu N., Ryan M. Young, Roland Schmitz, Sameer Jhavar, Wenming Xiao, Kian-Huat Lim, Holger Kohlhammer, et al. 2011. “Oncogenically Active Myd88 Mutations in Human Lymphoma.” Nature 470 (7332): 115–19. https://doi.org/10.1038/nature09671.
Okosun, Jessica, Rachel L. Wolfson, Jun Wang, Shamzah Araf, Lucy Wilkins, Brian M. Castellano, Leire Escudero-Ibarz, et al. 2016. “Recurrent mTORC1-activating RRAGC Mutations in Follicular Lymphoma.” Nature Genetics 48 (2): 183–88. https://doi.org/10.1038/ng.3473.
Otto, Claudia, Maciej Giefing, Anne Massow, Inga Vater, Stefan Gesk, Matthias Schlesner, Julia Richter, et al. 2012. “Genetic Lesions of the Traf3 and Map3k14 Genes in Classical Hodgkin Lymphoma.” British Journal of Haematology 157 (6): 702–8. https://doi.org/10.1111/j.1365-2141.2012.09113.x.
Panea, R., C. Love, Jennifer R. Shingleton, Anupama Reddy, J. Bailey, A. Moormann, J. Otieno, et al. 2019. “The Whole Genome Landscape of Burkitt Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2019001880.
Pararajalingam, Prasath, Krysta M. Coyle, Sarah E. Arthur, Nicole Thomas, Miguel Alcaide, Barbara Meissner, Merrill Boyle, et al. 2020. “Coding and Noncoding Drivers of Mantle Cell Lymphoma Identified Through Exome and Genome Sequencing.” Blood 136 (5): 572–84. https://doi.org/10.1182/blood.2019002385.
Parry, Marina, Matthew J. J. Rose-Zerilli, Jane Gibson, Sarah Ennis, Renata Walewska, Jade Forster, Helen Parker, et al. 2013. “Whole Exome Sequencing Identifies Novel Recurrently Mutated Genes in Patients with Splenic Marginal Zone Lymphoma.” PloS One 8 (12): e83244. https://doi.org/10.1371/journal.pone.0083244.
Pasqualucci, Laura, Mara Compagno, Jane Houldsworth, Stefano Monti, Adina Grunn, Subhadra V Nandula, Jon C Aster, Vundavally V Murty, Margaret A Shipp, and Riccardo Dalla-Favera. 2006. “Inactivation of the Prdm1/Blimp1 Gene in Diffuse Large B Cell Lymphoma.” J Exp Med 203 (2): 311–17.
Pasqualucci, Laura, David Dominguez-Sola, Annalisa Chiarenza, Giulia Fabbri, Adina Grunn, Vladimir Trifonov, Lawryn H. Kasper, et al. 2011. “Inactivating Mutations of Acetyltransferase Genes in B-cell Lymphoma.” Nature 471 (7337): 189–95. https://doi.org/10.1038/nature09730.
Pasqualucci, Laura, Vladimir Trifonov, Giulia Fabbri, Jing Ma, Davide Rossi, Annalisa Chiarenza, Victoria A. Wells, et al. 2011. “Analysis of the Coding Genome of Diffuse Large B-cell Lymphoma.” Nature Genetics 43 (9): 830–37. https://doi.org/10.1038/ng.892.
Pasqualucci, L., P. Neumeister, T. Goossens, G. Nanjangud, R. S. Chaganti, R. Küppers, and R. Dalla-Favera. 2001. “Hypermutation of Multiple Proto-Oncogenes in B-cell Diffuse Large-Cell Lymphomas.” Nature 412 (6844): 341–46. https://doi.org/10.1038/35085588.
Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell 171 (2): 481–494.e15.
Reichel, Jonathan, Amy Chadburn, Paul G. Rubinstein, Lisa Giulino-Roth, Wayne Tam, Yifang Liu, Rafael Gaiolla, et al. 2015. “Flow Sorting and Exome Sequencing Reveal the Oncogenome of Primary Hodgkin and Reed-Sternberg Cells.” Blood 125 (7): 1061–72. https://doi.org/10.1182/blood-2014-11-610436.
Richter, Julia, Matthias Schlesner, Steve Hoffmann, Markus Kreuz, Ellen Leich, Birgit Burkhardt, Maciej Rosolowski, et al. 2012. “Recurrent Mutation of the Id3 Gene in Burkitt Lymphoma Identified by Integrated Genome, Exome and Transcriptome Sequencing.” Nature Genetics 44 (12): 1316–20. https://doi.org/10.1038/ng.2469.
Ritz, Olga, Chrystelle Guiter, Flavia Castellano, Karola Dorsch, Julia Melzner, Jean-Philippe Jais, Gwendoline Dubois, Philippe Gaulard, Peter Möller, and Karen Leroy. 2009. “Recurrent Mutations of the Stat6 DNA Binding Domain in Primary Mediastinal B-cell Lymphoma.” Blood 114 (6): 1236–42. https://doi.org/10.1182/blood-2009-03-209759.
Rossi, Davide, Silvia Deaglio, David Dominguez-Sola, Silvia Rasi, Tiziana Vaisitti, Claudio Agostinelli, Valeria Spina, et al. 2011. “Alteration of Birc3 and Multiple Other NF-κB Pathway Genes in Splenic Marginal Zone Lymphoma.” Blood 118 (18): 4930–34. https://doi.org/10.1182/blood-2011-06-359166.
Rossi, Davide, Vladimir Trifonov, Marco Fangazio, Alessio Bruscaggin, Silvia Rasi, Valeria Spina, Sara Monti, et al. 2012. “The Coding Genome of Splenic Marginal Zone Lymphoma: Activation of Notch2 and Other Pathways Regulating Marginal Zone Development.” The Journal of Experimental Medicine 209 (9): 1537–51. https://doi.org/10.1084/jem.20120904.
Rushton, Christopher K., Sarah E. Arthur, Miguel Alcaide, Matthew Cheung, Aixiang Jiang, Krysta M. Coyle, Kirstie L. S. Cleary, et al. 2020. “Genetic and Evolutionary Patterns of Treatment Resistance in Relapsed B-cell Lymphoma.” Blood Advances 4 (13): 2886–98. https://doi.org/10.1182/bloodadvances.2020001696.
Russler-Germain, David A., Kilannin Krysiak, Cody A. Ramirez, Matthew Mosior, Marcus P. Watkins, Felicia Gomez, Zachary L. Skidmore, et al. 2023. “Mutations Associated with Progression in Follicular Lymphoma Predict Inferior Outcomes at Diagnosis: Alliance A151303.” Blood Advances 7: 5524–39. https://doi.org/10.1182/bloodadvances.2023010779.
Sarkozy, Clémentine, Stacy S. Hung, Elizabeth A. Chavez, Gerben Duns, Katsuyoshi Takata, Lauren C. Chong, Tomohiro Aoki, et al. 2021. “Mutational Landscape of Gray Zone Lymphoma.” Blood 137 (13): 1765–76. https://doi.org/10.1182/blood.2020007507.
Schmitz, Roland, Martin-Leo Hansmann, Verena Bohle, Jose Ignacio Martin-Subero, Sylvia Hartmann, Gunhild Mechtersheimer, Wolfram Klapper, et al. 2009. Tnfaip3 (A20) Is a Tumor Suppressor Gene in Hodgkin Lymphoma and Primary Mediastinal B Cell Lymphoma.” The Journal of Experimental Medicine 206 (5): 981–89. https://doi.org/10.1084/jem.20090528.
Schmitz, Roland, George W. Wright, Da Wei Huang, Calvin A. Johnson, James D. Phelan, James Q. Wang, Sandrine Roulland, et al. 2018. “Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma.” The New England Journal of Medicine 378 (15): 1396–1407. https://doi.org/10.1056/NEJMoa1801445.
Schmitz, Roland, Ryan M. Young, Michele Ceribelli, Sameer Jhavar, Wenming Xiao, Meili Zhang, George Wright, et al. 2012. “Burkitt Lymphoma Pathogenesis and Therapeutic Targets from Structural and Functional Genomics.” Nature 490 (7418): 116–20. https://doi.org/10.1038/nature11378.
Schneider, Markus, Stefanie Schneider, Reina Zühlke-Jenisch, Wolfram Klapper, Christer Sundström, Sylvia Hartmann, Martin-Leo Hansmann, Reiner Siebert, Ralf Küppers, and Maciej Giefing. 2015. “Alterations of the Cd58 Gene in Classical Hodgkin Lymphoma.” Genes, Chromosomes & Cancer 54 (10): 638–45. https://doi.org/10.1002/gcc.22276.
Scholl, Vanesa, Claudio Gustavo Stefanoff, Rocio Hassan, Nelson Spector, and Ilana Zalcberg Renault. 2007. “Mutations Within the 5’ Region of FAS/Cd95 Gene in Nodal Diffuse Large B-cell Lymphoma.” Leukemia & Lymphoma 48 (5): 957–63. https://doi.org/10.1080/10428190701230858.
Shin, Sang-Yong, Seung-Tae Lee, Hee-Jin Kim, Chang-Seok Ki, Chul Won Jung, Jong-Won Kim, and Sun-Hee Kim. 2015. BRAF V600e and Map2k1 Mutations in Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma Cases.” Annals of Laboratory Medicine 35 (2): 257–59. https://doi.org/10.3343/alm.2015.35.2.257.
Spina, Valeria, Hossein Khiabanian, Monica Messina, Sara Monti, Luciano Cascione, Alessio Bruscaggin, Elisa Spaccarotella, et al. 2016. “The Genetics of Nodal Marginal Zone Lymphoma.” Blood 128 (10): 1362–73. https://doi.org/10.1182/blood-2016-02-696757.
Tanaka, S., D. C. Louie, J. A. Kant, and J. C. Reed. 1992. “Frequent Incidence of Somatic Mutations in Translocated Bcl2 Oncogenes of Non-Hodgkin’s Lymphomas.” Blood 79 (1): 229–37. https://doi.org/10.1182/blood.V79.1.229.229.
Thomas, Nicole, Kostiantyn Dreval, Daniela S. Gerhard, Laura K. Hilton, Jeremy S. Abramson, Richard F. Ambinder, Stefan Barta, et al. 2023. “Genetic Subgroups Inform on Pathobiology in Adult and Pediatric Burkitt Lymphoma.” Blood 141 (8): 904–16. https://doi.org/10.1182/blood.2022016534.
Tiacci, Enrico, Erik Ladewig, Gianluca Schiavoni, Alex Penson, Elisabetta Fortini, Valentina Pettirossi, Yuchun Wang, et al. 2018. “Pervasive Mutations of JAK-STAT Pathway Genes in Classical Hodgkin Lymphoma.” Blood 131 (22): 2454–65. https://doi.org/10.1182/blood-2017-11-814913.
Tiacci, Enrico, Vladimir Trifonov, Gianluca Schiavoni, Antony Holmes, Wolfgang Kern, Maria Paola Martelli, Alessandra Pucciarini, et al. 2011. BRAF Mutations in Hairy-Cell Leukemia.” The New England Journal of Medicine 364 (24): 2305–15. https://doi.org/10.1056/NEJMoa1014209.
Viganò, Elena, Jay Gunawardana, Anja Mottok, Tessa Van Tol, Katina Mak, Fong Chun Chan, Lauren Chong, et al. 2018. “Somatic Il4r Mutations in Primary Mediastinal Large B-cell Lymphoma Lead to Constitutive JAK-STAT Signaling Activation.” Blood 131 (18): 2036–46. https://doi.org/10.1182/blood-2017-09-808907.
Weniger, M. A., I. Melzner, C. K. Menz, S. Wegener, A. J. Bucur, K. Dorsch, T. Mattfeldt, T. F. E. Barth, and P. Möller. 2006. “Mutations of the Tumor Suppressor Gene SOCS-1 in Classical Hodgkin Lymphoma Are Frequent and Associated with Nuclear Phospho-Stat5 Accumulation.” Oncogene 25 (18): 2679–84. https://doi.org/10.1038/sj.onc.1209151.
Wienand, Kirsty, Bjoern Chapuy, Chip Stewart, Andrew J. Dunford, David Wu, Jaegil Kim, Atanas Kamburov, et al. 2019. “Genomic Analyses of Flow-Sorted Hodgkin Reed-Sternberg Cells Reveal Complementary Mechanisms of Immune Evasion.” Blood Advances 3 (23): 4065–80. https://doi.org/10.1182/bloodadvances.2019001012.
Wilda, M., J. Bruch, L. Harder, D. Rawer, A. Reiter, A. Borkhardt, and W. Woessmann. 2004. “Inactivation of the ARF-MDM-2-p53 Pathway in Sporadic Burkitt’s Lymphoma in Children.” Leukemia 18 (3): 584–88. https://doi.org/10.1038/sj.leu.2403254.
Wu, Chenglin, Noel Fcc de Miranda, Longyun Chen, Agata M. Wasik, Larry Mansouri, Wojciech Jurczak, Krystyna Galazka, et al. 2016. “Genetic Heterogeneity in Primary and Relapsed Mantle Cell Lymphomas: Impact of Recurrent Card11 Mutations.” Oncotarget 7 (25): 38180–90. https://doi.org/10.18632/oncotarget.9500.
Yan, Qingguo, Yuanxue Huang, A. James Watkins, Sylvia Kocialkowski, Naiyan Zeng, Rifat A. Hamoudi, Peter G. Isaacson, Laurence de Leval, Andrew Wotherspoon, and Ming-Qing Du. 2012. BCR and TLR Signaling Pathways Are Recurrently Targeted by Genetic Changes in Splenic Marginal Zone Lymphomas.” Haematologica 97 (4): 595–98. https://doi.org/10.3324/haematol.2011.054080.
Yildiz, Mehmet, Hongxiu Li, Denzil Bernard, Nisar A. Amin, Peter Ouillette, Siân Jones, Kamlai Saiya-Cork, et al. 2015. “Activating Stat6 Mutations in Follicular Lymphoma.” Blood 125 (4): 668–79. https://doi.org/10.1182/blood-2014-06-582650.
Zhang, Jenny, Vladimir Grubor, Cassandra L Love, Anjishnu Banerjee, Kristy L Richards, Piotr A Mieczkowski, Cherie Dunphy, et al. 2013. “Genetic Heterogeneity of Diffuse Large B-cell Lymphoma.” Proceedings of the National Academy of Sciences of the United States of America 110: 1398–1403. https://doi.org/10.1073/pnas.1205299110.
Zhang, Jenny, Dereje Jima, Andrea B. Moffitt, Qingquan Liu, Magdalena Czader, Eric D. Hsi, Yuri Fedoriw, et al. 2014. “The Genomic Landscape of Mantle Cell Lymphoma Is Related to the Epigenetically Determined Chromatin State of Normal B Cells.” Blood 123 (19): 2988–96. https://doi.org/10.1182/blood-2013-07-517177.
Zhou, Peixun, Alex E. Blain, Alexander M. Newman, Masood Zaka, George Chagaluka, Filbert R. Adlar, Ugonna T. Offor, et al. 2019. “Sporadic and Endemic Burkitt Lymphoma Have Frequent Foxo1 Mutations but Distinct Hotspots in the AKT Recognition Motif.” Blood Advances 3 (14): 2118–27. https://doi.org/10.1182/bloodadvances.2018029546.