Origins of MCL genes

Tier 1 MCL genes

Gene Status First MCL study Other lists
ATM MCL Tier 1 Bea et al DLBCL, MZL
BIRC3 MCL Tier 1 Bea et al DLBCL, MZL, PMBL
CARD11 MCL Tier 1 Wu et al DLBCL, MZL, FL, BL
CCND1 MCL Tier 1 Bea et al
DAZAP1 MCL Tier 1 Pararajalingam et al DLBCL
EWSR1 MCL Tier 1 Pararajalingam et al PMBL
HNRNPH1 MCL Tier 1 Pararajalingam et al DLBCL
KMT2D MCL Tier 1 Bea et al FL, BL, DLBCL, PMBL, MZL
MEF2B MCL Tier 1 Bea et al FL, DLBCL
NFKBIE MCL Tier 1 Pararajalingam et al DLBCL, PMBL
NOTCH1 MCL Tier 1 Bea et al MZL, DLBCL, BL
NOTCH2 MCL Tier 1 Bea et al MZL, DLBCL
NSD2 MCL Tier 1 Bea et al DLBCL
POT1 MCL Tier 1 Zhang et al
RB1 MCL Tier 1 Zhang et al DLBCL
S1PR1 MCL Tier 1 Pararajalingam et al DLBCL
SMARCA4 MCL Tier 1 Nadeu et al DLBCL, BL, FL, PMBL
SP140 MCL Tier 1 Bea et al
SYNE1 MCL Tier 1 Nadeu et al
TERT MCL Tier 1 Nadeu et al
TLR2 MCL Tier 1 Bea et al DLBCL
TP53 MCL Tier 1 Bea et al PMBL, DLBCL, FL, BL, MZL
UBR5 MCL Tier 1 Pararajalingam et al DLBCL

Tier 2 MCL genes

Gene Status First MCL study Other lists
ABCA3 MCL Tier 2 Bea et al DLBCL
ABCC9 MCL Tier 2 Bea et al
ANK2 MCL Tier 2 Zhang et al DLBCL
ARID1B MCL Tier 2 Freeman et al
ATP11C MCL Tier 2 Zhang et al
B2M MCL Tier 2 Pararajalingam et al DLBCL, PMBL
BCOR MCL Tier 2 Nadeu et al MZL
CDH8 MCL Tier 2 Zhang et al DLBCL
CHMP4C MCL Tier 2 Bea et al
COL11A1 MCL Tier 2 Zhang et al
COL16A1 MCL Tier 2 Zhang et al
CRYBG3 MCL Tier 2 Bea et al
CTNNA2 MCL Tier 2 Zhang et al
DCP1B MCL Tier 2 Bea et al
DHDH MCL Tier 2 Zhang et al
DLC1 MCL Tier 2 Zhang et al
DLGAP2 MCL Tier 2 Bea et al
DNAJC6 MCL Tier 2 Bea et al
EIF2AK4 MCL Tier 2 Zhang et al
ESX1 MCL Tier 2 Zhang et al
FAT4 MCL Tier 2 Zhang et al DLBCL, MZL
GRIN2A MCL Tier 2 Zhang et al
HEPH MCL Tier 2 Zhang et al
KCNC2 MCL Tier 2 Bea et al
KIAA1671 MCL Tier 2 Bea et al
KMT2C MCL Tier 2 Zhang et al PMBL, DLBCL, BL
LUZP4 MCL Tier 2 Bea et al
MRGPRF MCL Tier 2 Zhang et al
NIN MCL Tier 2 Zhang et al
OGDHL MCL Tier 2 Zhang et al
PCDHB2 MCL Tier 2 Zhang et al
PCSK2 MCL Tier 2 Bea et al
PDLIM3 MCL Tier 2 Bea et al
PLXNB3 MCL Tier 2 Zhang et al DLBCL
RGS4 MCL Tier 2 Bea et al
ROBO2 MCL Tier 2 Zhang et al
SALL3 MCL Tier 2 Zhang et al BL
SI MCL Tier 2 Zhang et al
SLC17A6 MCL Tier 2 Bea et al
SMARCB1 MCL Tier 2 Nadeu et al
SMC1A MCL Tier 2 Zhang et al
TBC1D26 MCL Tier 2 Zhang et al
TNRC6B MCL Tier 2 Bea et al
TRPM6 MCL Tier 2 Bea et al
ZNF117 MCL Tier 2 Zhang et al
ZNF296 MCL Tier 2 Zhang et al

References

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Freeman CL, Pararajalingam P, Jin L, Balasubramanian S, Jiang A, Xu W, Grau M, Zapukhlyak M, Boyle M, Hodkinson B, Schaffer M, Enny C, Deshpande S, Sun S, Vermeulen J, Morin RD, Scott DW, Lenz G. Molecular determinants of outcomes in relapsed or refractory mantle cell lymphoma treated with ibrutinib or temsirolimus in the MCL3001 (RAY) trial. Leukemia. 2022 Oct;36(10):2479–2487.
2.
Beà S, Valdés-Mas R, Navarro A, Salaverria I, Martín-Garcia D, Jares P, Giné E, Pinyol M, Royo C, Nadeu F, Conde L, Juan M, Clot G, Vizán P, Croce LD, Puente DA, López-Guerra M, Moros A, Roue G, Aymerich M, Villamor N, Colomo L, Martínez A, Valera A, Martín-Subero JI, Amador V, Hernández L, Rozman M, Enjuanes A, Forcada P, Muntañola A, Hartmann EM, Calasanz MJ, Rosenwald A, Ott G, Hernández-Rivas JM, Klapper W, Siebert R, Wiestner A, Wilson WH, Colomer D, López-Guillermo A, López-Otín C, Puente XS, Campo E. Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. PNAS. 2013;110(45):18250–18255.
3.
Pararajalingam P, Coyle KM, Arthur SE, Thomas N, Alcaide M, Meissner B, Boyle M, Qureshi Q, Grande BM, Rushton C, Slack GW, Mungall AJ, Tam CS, Agarwal R, Dawson SJ, Lenz G, Balasubramanian S, Gascoyne RD, Steidl C, Connors J, Villa D, Audas TE, Marra MA, Johnson NA, Scott DW, Morin RD. Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing. Blood. 2020 Jul 30;136(5):572–584. PMCID: PMC7440974
4.
Wu C, de Miranda NF, Chen L, Wasik AM, Mansouri L, Jurczak W, Galazka K, Dlugosz-Danecka M, Machaczka M, Zhang H, Peng R, Morin RD, Rosenquist R, Sander B, Pan-Hammarström Q. Genetic heterogeneity in primary and relapsed mantle cell lymphomas: Impact of recurrent CARD11 mutations. Oncotarget. 2016 Jun 21;7(25):38180–38190. PMCID: PMC5122381
5.
Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED, Fedoriw Y, Dunphy CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P, Lock E, Levy S, Hsu DS, Dunson D, Dave SS. The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood. 2014 May 8;123(19):2988–2996.

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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