Origins of BL genes

Tier 1 BL genes

Gene Status First BL study Other lists
ARID1A BL Tier 1 Love et al DLBCL, FL, PMBL, MZL
BACH2 BL Tier 1 Grande et al
BCL6 BL Tier 1 Love et al DLBCL, FL
BCL7A BL Tier 1 Grande et al DLBCL, FL, PMBL, MZL
BMP7 BL Tier 1 Panea et al
CCND3 BL Tier 1 Richter et al DLBCL, FL, PMBL, MZL
CHD8 BL Tier 1 Grande et al PMBL
CREBBP BL Tier 1 Love et al DLBCL, FL, PMBL, MZL
DDX3X BL Tier 1 Schmitz et al DLBCL, FL, PMBL
EZH2 BL Tier 1 Love et al DLBCL, FL, PMBL, MZL
FBXO11 BL Tier 1 Richter et al DLBCL, MZL
FOXO1 BL Tier 1 Schmitz et al DLBCL, FL, PMBL, MZL
GNA13 BL Tier 1 Schmitz et al DLBCL, FL, PMBL
GNAI2 BL Tier 1 Grande et al DLBCL, FL
HIST1H1E BL Tier 1 Grande et al DLBCL, FL, PMBL
HNRNPU BL Tier 1 Panea et al DLBCL
ID3 BL Tier 1 Richter et al DLBCL, MZL
IGLL5 BL Tier 1 Panea et al DLBCL, FL, PMBL
KMT2D BL Tier 1 Grande et al DLBCL, FL, PMBL, MCL, MZL
MYC BL Tier 1 Johnston et al DLBCL, FL, PMBL, MZL
P2RY8 BL Tier 1 Muppidi et al DLBCL, FL, PMBL
PCBP1 BL Tier 1 Schmitz et al PMBL
PHF6 BL Tier 1 Thomas et al DLBCL
PTEN BL Tier 1 Love et al DLBCL
RFX7 BL Tier 1 Grande et al DLBCL
RHOA BL Tier 1 Richter et al DLBCL, FL, PMBL
SIN3A BL Tier 1 Grande et al DLBCL, PMBL, MZL
SMARCA4 BL Tier 1 Richter et al DLBCL, FL, PMBL, MCL
TCF3 BL Tier 1 Schmitz et al PMBL
TCL1A BL Tier 1 Grande et al DLBCL
TFAP4 BL Tier 1 Grande et al
TP53 BL Tier 1 Wilda et al DLBCL, FL, PMBL, MCL, MZL
USP7 BL Tier 1 Grande et al DLBCL
WNK1 BL Tier 1 Thomas et al DLBCL, MZL

Tier 2 BL genes

Gene Status First BL study Other lists
ADAMTS5 BL Tier 2 Burkhardt et al
ADNP BL Tier 2 Burkhardt et al
AGO4 BL Tier 2 Burkhardt et al
ARHGEF1 BL Tier 2 Muppidi et al
B2M BL Tier 2 Ma et al DLBCL, FL, PMBL, MCL
BCL2 BL Tier 2 Burkhardt et al DLBCL, FL, PMBL
BTG1 BL Tier 2 Burkhardt et al DLBCL, FL, PMBL, MZL
C16orf48 BL Tier 2 Schmitz et al
CARD11 BL Tier 2 Ma et al DLBCL, FL, MCL, MZL
CARD4 BL Tier 2 Love et al
CCNF BL Tier 2 Abate et al DLBCL
CD79A BL Tier 2 Burkhardt et al MZL
CD83 BL Tier 2 Panea et al DLBCL, FL, PMBL
CDC27 BL Tier 2 Ma et al
CDC73 BL Tier 2 Love et al DLBCL
CDKN2A BL Tier 2 Grande et al DLBCL, PMBL, MZL
CDKN2C BL Tier 2 Thomas et al
CHD4 BL Tier 2 Burkhardt et al
CPXM2 BL Tier 2 Burkhardt et al
CXCR4 BL Tier 2 Panea et al DLBCL, FL, MZL
DHCR7 BL Tier 2 Schmitz et al
E2F2 BL Tier 2 Burkhardt et al
EBF1 BL Tier 2 Thomas et al DLBCL, FL, PMBL
EDNRB BL Tier 2 Burkhardt et al
EHD1 BL Tier 2 Thomas et al
EIF4A1 BL Tier 2 Panea et al
ELP2 BL Tier 2 Schmitz et al
EPPK1 BL Tier 2 Panea et al
ERAP1 BL Tier 2 Burkhardt et al
EXOSC6 BL Tier 2 Schmitz et al
FLYWCH1 BL Tier 2 Schmitz et al
GGTLA4 BL Tier 2 Love et al
GTSE1 BL Tier 2 Schmitz et al
HIST1H1B BL Tier 2 Ma et al DLBCL, FL, PMBL
HIST1H3D BL Tier 2 Panea et al
HIST1H3I BL Tier 2 Panea et al FL
HIST1H4J BL Tier 2 Panea et al PMBL
HLA-DQB1 BL Tier 2 Burkhardt et al
IKZF3 BL Tier 2 Panea et al DLBCL
IRF8 BL Tier 2 Panea et al DLBCL, FL, PMBL
KANK2 BL Tier 2 Schmitz et al
KLHL26 BL Tier 2 Burkhardt et al
KMT2C BL Tier 2 Zhou et al DLBCL, PMBL, MCL
MCL1 BL Tier 2 Panea et al DLBCL, PMBL
MIR142 BL Tier 2 Grande et al DLBCL
MKI67 BL Tier 2 Schmitz et al FL
MYO18A BL Tier 2 Schmitz et al
NBEAL1 BL Tier 2 Love et al
NCOR2 BL Tier 2 Schmitz et al PMBL, MZL
NOA1 BL Tier 2 Burkhardt et al
P2RY2 BL Tier 2 Love et al
PDCD11 BL Tier 2 Schmitz et al
PIM1 BL Tier 2 Burkhardt et al DLBCL, FL, PMBL
PLCG2 BL Tier 2 Panea et al DLBCL
PPP6R2 BL Tier 2 Burkhardt et al
PRDM1 BL Tier 2 Ma et al DLBCL
PREX1 BL Tier 2 Burkhardt et al
RANBP6 BL Tier 2 Love et al
REV3L BL Tier 2 Burkhardt et al
RNF144B BL Tier 2 Panea et al
RPL10 BL Tier 2 Burkhardt et al
S1PR2 BL Tier 2 Muppidi et al DLBCL, FL, PMBL
SAL3 BL Tier 2 Burkhardt et al
TBL1XR1 BL Tier 2 Ma et al DLBCL, FL, PMBL, MZL
TET2 BL Tier 2 Thomas et al DLBCL
TNFRSF14 BL Tier 2 Ma et al DLBCL, FL, MZL
TOP2A BL Tier 2 Schmitz et al
TTN BL Tier 2 Burkhardt et al
VWA7 BL Tier 2 Burkhardt et al
WDR90 BL Tier 2 Schmitz et al
WHAMM BL Tier 2 Schmitz et al
WNK2 BL Tier 2 Panea et al
YY1AP1 BL Tier 2 Schmitz et al
ZAN BL Tier 2 Burkhardt et al
ZBTB7A BL Tier 2 Burkhardt et al DLBCL
ZFP36L1 BL Tier 2 Panea et al DLBCL, PMBL
ZNF85 BL Tier 2 Burkhardt et al

Tier 3 BL genes

Gene Status First BL study Other lists
ACAD9 BL Tier 3 Love et al
ACE BL Tier 3 Love et al DLBCL
ALPK2 BL Tier 3 Panea et al
ATP2C2 BL Tier 3 Love et al
BRAF BL Tier 3 Love et al DLBCL, MZL
BRD4 BL Tier 3 Love et al DLBCL
BTG2 BL Tier 3 Love et al DLBCL, FL
C6orf27 BL Tier 3 Love et al
CAD BL Tier 3 Love et al DLBCL
CCT6B BL Tier 3 Love et al
CD79B BL Tier 3 Panea et al DLBCL, FL
CDH17 BL Tier 3 Love et al
COL4A2 BL Tier 3 Love et al
CTCF BL Tier 3 Panea et al
CYB5D1 BL Tier 3 Love et al
CYP4F22 BL Tier 3 Love et al
DLGAP1 BL Tier 3 Love et al DLBCL
DNMT1 BL Tier 3 Panea et al
DTX1 BL Tier 3 Love et al DLBCL, PMBL, MZL
EIF2C4 BL Tier 3 Love et al
EML2 BL Tier 3 Love et al
ENTPD3 BL Tier 3 Love et al
EPHB2 BL Tier 3 Love et al
ETS1 BL Tier 3 Panea et al DLBCL, PMBL
FAM129B BL Tier 3 Love et al
FGFR3 BL Tier 3 Love et al
FTCD BL Tier 3 Love et al
FZD3 BL Tier 3 Panea et al
GRIK5 BL Tier 3 Love et al
HIST1H1C BL Tier 3 Panea et al DLBCL, FL, PMBL
HIST1H2AG BL Tier 3 Panea et al DLBCL, FL, MZL
HIST1H2AM BL Tier 3 Panea et al DLBCL, FL
HIST1H2BK BL Tier 3 Panea et al DLBCL, MZL
HIST1H3H BL Tier 3 Panea et al
HIST1H3J BL Tier 3 Panea et al
ICK BL Tier 3 Love et al
ITPR3 BL Tier 3 Love et al PMBL
KCNK10 BL Tier 3 Panea et al
KIFC3 BL Tier 3 Love et al
MAP3K6 BL Tier 3 Love et al
MME BL Tier 3 Panea et al
MTOR BL Tier 3 Panea et al DLBCL
MYH10 BL Tier 3 Love et al
NOTCH1 BL Tier 3 Love et al DLBCL, MCL, MZL
NRXN2 BL Tier 3 Love et al DLBCL
PABPC4L BL Tier 3 Panea et al
PC BL Tier 3 Love et al
PCDHA11 BL Tier 3 Panea et al
PDZRN3 BL Tier 3 Panea et al DLBCL
PIK3R1 BL Tier 3 Panea et al DLBCL
POLRMT BL Tier 3 Love et al
POR BL Tier 3 Love et al
PRSS22 BL Tier 3 Love et al
PTPRN BL Tier 3 Love et al
PXDNL BL Tier 3 Panea et al
RBP3 BL Tier 3 Love et al DLBCL
RET BL Tier 3 Love et al DLBCL
SALL3 BL Tier 3 Love et al MCL
SAPS2 BL Tier 3 Love et al
SBF1 BL Tier 3 Love et al
SF3B1 BL Tier 3 Love et al DLBCL
SHANK1 BL Tier 3 Love et al
SLC29A2 BL Tier 3 Love et al
SNTB2 BL Tier 3 Panea et al
SYNGAP1 BL Tier 3 Love et al
TBC1D9B BL Tier 3 Love et al
TIGD6 BL Tier 3 Love et al
TPST2 BL Tier 3 Love et al
WDR7 BL Tier 3 Panea et al
ZNF229 BL Tier 3 Love et al

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