Clinical relevance
Therapeutic targets
| Gene | Status | Entity | Therapy | Biomarkers |
|---|---|---|---|---|
| BCL2 | not approved | DLBCL | venetoclax | Not applicable |
| BTK | not approved | DLBCL | ibrutinib | ABC gene expression signature, MCD genetic subgroup |
| CD79B | FDA approved | DLBCL | polatuzumab vedotin | ABC gene expression signature |
| EZH2 | FDA approved | FL | tazemetostat | Mutation |
| XPO1 | FDA approved | DLBCL | selinexor | Not applicable |